Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs

Ibuprofen is a non-steroidal anti-inflammatory drug that has a disadvantage in its oral use, such as gastrointestinal disorders, nausea, vomiting and gastric ulcers. Transdermal patch dosage forms are an alternative in overcoming this weakness. The transdermal patch is formulated using a special mem...

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Autores principales:	Shaum Shiyan, Misirti Maulidia Anis Marketama, Galih Pratiwi
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Ahmad Dahlan 2021
Materias:	ibuprofen transdermal patch full factorial design chitosan hpmc Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/eb9da8778f8145078389a921b8830f08
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spelling	oai:doaj.org-article:eb9da8778f8145078389a921b8830f082021-11-18T01:00:00Z Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs10.12928/pharmaciana.v11i3.199352088-45592477-0256https://doaj.org/article/eb9da8778f8145078389a921b8830f082021-11-01T00:00:00Zhttp://journal.uad.ac.id/index.php/PHARMACIANA/article/view/19935/pdf_212https://doaj.org/toc/2088-4559https://doaj.org/toc/2477-0256Ibuprofen is a non-steroidal anti-inflammatory drug that has a disadvantage in its oral use, such as gastrointestinal disorders, nausea, vomiting and gastric ulcers. Transdermal patch dosage forms are an alternative in overcoming this weakness. The transdermal patch is formulated using a special membrane that can control drug release in a matrix system. Therefore, this study optimizes chitosan and HPMC as polymers using a factorial design approach. The parameters tested included weight uniformity, patch thickness, swelling index, in vitro release rate, folding resistance, ibuprofen uniformity, surface pH, and moisture content. The interactions between the components were evaluated using Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR). The optimum concentration of chitosan was 0.5% and HPMC 6% with CV values for weight uniformity of 0.003 ± 1.202%; humidity 0.543 ± 5.595%; swelling index 4.611 ± 23,657%; thickness 0.052 ± 2.428%; surface pH 5; durability is less than 300 times and the uniformity of ibuprofen levels is 1.52 ± 2.99%. The design approach using the FFD22 obtained an effective and efficient mathematical-statistical model to determine the optimal polymer combination in the formula. As an additional instrument in design evaluation, the chemometric approach is constructive in modeling and optimization. Shaum Shiyan Misirti Maulidia Anis MarketamaGalih PratiwiUniversitas Ahmad Dahlanarticleibuprofentransdermal patchfull factorial designchitosanhpmcPharmacy and materia medicaRS1-441ENPharmaciana, Vol 11, Iss 3, Pp 406-415 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ibuprofen transdermal patch full factorial design chitosan hpmc Pharmacy and materia medica RS1-441
spellingShingle	ibuprofen transdermal patch full factorial design chitosan hpmc Pharmacy and materia medica RS1-441 Shaum Shiyan Misirti Maulidia Anis Marketama Galih Pratiwi Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs
description	Ibuprofen is a non-steroidal anti-inflammatory drug that has a disadvantage in its oral use, such as gastrointestinal disorders, nausea, vomiting and gastric ulcers. Transdermal patch dosage forms are an alternative in overcoming this weakness. The transdermal patch is formulated using a special membrane that can control drug release in a matrix system. Therefore, this study optimizes chitosan and HPMC as polymers using a factorial design approach. The parameters tested included weight uniformity, patch thickness, swelling index, in vitro release rate, folding resistance, ibuprofen uniformity, surface pH, and moisture content. The interactions between the components were evaluated using Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR). The optimum concentration of chitosan was 0.5% and HPMC 6% with CV values for weight uniformity of 0.003 ± 1.202%; humidity 0.543 ± 5.595%; swelling index 4.611 ± 23,657%; thickness 0.052 ± 2.428%; surface pH 5; durability is less than 300 times and the uniformity of ibuprofen levels is 1.52 ± 2.99%. The design approach using the FFD22 obtained an effective and efficient mathematical-statistical model to determine the optimal polymer combination in the formula. As an additional instrument in design evaluation, the chemometric approach is constructive in modeling and optimization.
format	article
author	Shaum Shiyan Misirti Maulidia Anis Marketama Galih Pratiwi
author_facet	Shaum Shiyan Misirti Maulidia Anis Marketama Galih Pratiwi
author_sort	Shaum Shiyan
title	Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs
title_short	Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs
title_full	Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs
title_fullStr	Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs
title_full_unstemmed	Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs
title_sort	optimization transdermal patch of polymer combination of chitosan and hpmc-loaded ibuprofen using factorial designs
publisher	Universitas Ahmad Dahlan
publishDate	2021
url	https://doaj.org/article/eb9da8778f8145078389a921b8830f08
work_keys_str_mv	AT shaumshiyan optimizationtransdermalpatchofpolymercombinationofchitosanandhpmcloadedibuprofenusingfactorialdesigns AT misirtimaulidiaanismarketama optimizationtransdermalpatchofpolymercombinationofchitosanandhpmcloadedibuprofenusingfactorialdesigns AT galihpratiwi optimizationtransdermalpatchofpolymercombinationofchitosanandhpmcloadedibuprofenusingfactorialdesigns
_version_	1718425196804702208

Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs

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