Retroviral integrations contribute to elevated host cancer rates during germline invasion

Koalas are susceptible to neoplasms, which are related to infection with the Koala retrovirus. Here, the authors use DNA sequencing to show that the retroviral insertion sites cluster near known cancer genes and demonstrate a high mutational load associated with the germline invasion of the virus.

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Autores principales:	Gayle K. McEwen, David E. Alquezar-Planas, Anisha Dayaram, Amber Gillett, Rachael Tarlinton, Nigel Mongan, Keith J. Chappell, Joerg Henning, Milton Tan, Peter Timms, Paul R. Young, Alfred L. Roca, Alex D. Greenwood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eba0ba36c09b41ff9f15e4e63b2dfe03
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spelling	oai:doaj.org-article:eba0ba36c09b41ff9f15e4e63b2dfe032021-12-02T13:15:06ZRetroviral integrations contribute to elevated host cancer rates during germline invasion10.1038/s41467-021-21612-72041-1723https://doaj.org/article/eba0ba36c09b41ff9f15e4e63b2dfe032021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21612-7https://doaj.org/toc/2041-1723Koalas are susceptible to neoplasms, which are related to infection with the Koala retrovirus. Here, the authors use DNA sequencing to show that the retroviral insertion sites cluster near known cancer genes and demonstrate a high mutational load associated with the germline invasion of the virus.Gayle K. McEwenDavid E. Alquezar-PlanasAnisha DayaramAmber GillettRachael TarlintonNigel MonganKeith J. ChappellJoerg HenningMilton TanPeter TimmsPaul R. YoungAlfred L. RocaAlex D. GreenwoodNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gayle K. McEwen David E. Alquezar-Planas Anisha Dayaram Amber Gillett Rachael Tarlinton Nigel Mongan Keith J. Chappell Joerg Henning Milton Tan Peter Timms Paul R. Young Alfred L. Roca Alex D. Greenwood Retroviral integrations contribute to elevated host cancer rates during germline invasion
description	Koalas are susceptible to neoplasms, which are related to infection with the Koala retrovirus. Here, the authors use DNA sequencing to show that the retroviral insertion sites cluster near known cancer genes and demonstrate a high mutational load associated with the germline invasion of the virus.
format	article
author	Gayle K. McEwen David E. Alquezar-Planas Anisha Dayaram Amber Gillett Rachael Tarlinton Nigel Mongan Keith J. Chappell Joerg Henning Milton Tan Peter Timms Paul R. Young Alfred L. Roca Alex D. Greenwood
author_facet	Gayle K. McEwen David E. Alquezar-Planas Anisha Dayaram Amber Gillett Rachael Tarlinton Nigel Mongan Keith J. Chappell Joerg Henning Milton Tan Peter Timms Paul R. Young Alfred L. Roca Alex D. Greenwood
author_sort	Gayle K. McEwen
title	Retroviral integrations contribute to elevated host cancer rates during germline invasion
title_short	Retroviral integrations contribute to elevated host cancer rates during germline invasion
title_full	Retroviral integrations contribute to elevated host cancer rates during germline invasion
title_fullStr	Retroviral integrations contribute to elevated host cancer rates during germline invasion
title_full_unstemmed	Retroviral integrations contribute to elevated host cancer rates during germline invasion
title_sort	retroviral integrations contribute to elevated host cancer rates during germline invasion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eba0ba36c09b41ff9f15e4e63b2dfe03
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Retroviral integrations contribute to elevated host cancer rates during germline invasion

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