A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality

Abstract Disruptions in fear-extinction learning are centrally implicated in a range of stress-related disorders, including anxiety and posttraumatic stress disorder. Given that these disorders frequently begin in childhood/adolescence, an understanding of fear-extinction learning in children is ess...

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Autores principales:	Hilary A. Marusak, Craig A. Peters, Aneesh Hehr, Farrah Elrahal, Christine A. Rabinak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eba57d1b2aae4e9094fa4404695db159
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spelling	oai:doaj.org-article:eba57d1b2aae4e9094fa4404695db1592021-12-02T15:04:52ZA novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality10.1038/s41598-017-17131-52045-2322https://doaj.org/article/eba57d1b2aae4e9094fa4404695db1592017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-17131-5https://doaj.org/toc/2045-2322Abstract Disruptions in fear-extinction learning are centrally implicated in a range of stress-related disorders, including anxiety and posttraumatic stress disorder. Given that these disorders frequently begin in childhood/adolescence, an understanding of fear-extinction learning in children is essential for (1) detecting the source of developmental susceptibility, (2) identifying mechanisms leading to pathology, and (3) informing the development and/or more judicious application of treatments for youth. Here, we offer and validate a novel virtual reality paradigm to study threat-related learning and extinction in children that models real-world cues, environments, and fear-inducing events that children are likely to experience, and are linked to the development of fear- and stress-related pathologies. We found that our paradigm is well tolerated in children as young as 6 years, that children show intact fear and extinction learning, and show evidence of divergence in subjective, physiological, and behavioral measures of conditioned fear. The paradigm is available for use in 3-D and in 2-D (e.g., for the MRI scanner) upon request at www.tnp2lab.org .Hilary A. MarusakCraig A. PetersAneesh HehrFarrah ElrahalChristine A. RabinakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hilary A. Marusak Craig A. Peters Aneesh Hehr Farrah Elrahal Christine A. Rabinak A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality
description	Abstract Disruptions in fear-extinction learning are centrally implicated in a range of stress-related disorders, including anxiety and posttraumatic stress disorder. Given that these disorders frequently begin in childhood/adolescence, an understanding of fear-extinction learning in children is essential for (1) detecting the source of developmental susceptibility, (2) identifying mechanisms leading to pathology, and (3) informing the development and/or more judicious application of treatments for youth. Here, we offer and validate a novel virtual reality paradigm to study threat-related learning and extinction in children that models real-world cues, environments, and fear-inducing events that children are likely to experience, and are linked to the development of fear- and stress-related pathologies. We found that our paradigm is well tolerated in children as young as 6 years, that children show intact fear and extinction learning, and show evidence of divergence in subjective, physiological, and behavioral measures of conditioned fear. The paradigm is available for use in 3-D and in 2-D (e.g., for the MRI scanner) upon request at www.tnp2lab.org .
format	article
author	Hilary A. Marusak Craig A. Peters Aneesh Hehr Farrah Elrahal Christine A. Rabinak
author_facet	Hilary A. Marusak Craig A. Peters Aneesh Hehr Farrah Elrahal Christine A. Rabinak
author_sort	Hilary A. Marusak
title	A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality
title_short	A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality
title_full	A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality
title_fullStr	A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality
title_full_unstemmed	A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality
title_sort	novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/eba57d1b2aae4e9094fa4404695db159
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A novel paradigm to study interpersonal threat-related learning and extinction in children using virtual reality

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