Human placental perfusion measured using dynamic contrast enhancement MRI.

Human placental perfusion measured using dynamic contrast enhancement MRI.

<h4>Objectives</h4>To evaluate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and measure values of in vivo placental perfusion in women.<h4>Methods</h4>This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enh...

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Autores principales: Benjamin Deloison, Chloé Arthuis, Gabriel Benchimol, Daniel Balvay, Laurence Bussieres, Anne-Elodie Millischer, David Grévent, Cécile Butor, Gihad Chalouhi, Houman Mahallati, Olivier Hélénon, Bertrand Tavitian, Olivier Clement, Yves Ville, Nathalie Siauve, Laurent Julien Salomon
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Medicine
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Science
Q
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spelling oai:doaj.org-article:ebaaca519f4f4a029978625e8a9d787a2021-12-02T20:08:37ZHuman placental perfusion measured using dynamic contrast enhancement MRI.1932-620310.1371/journal.pone.0256769https://doaj.org/article/ebaaca519f4f4a029978625e8a9d787a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256769https://doaj.org/toc/1932-6203<h4>Objectives</h4>To evaluate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and measure values of in vivo placental perfusion in women.<h4>Methods</h4>This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses.<h4>Results</h4>134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA.<h4>Conclusions</h4>Measuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies.Benjamin DeloisonChloé ArthuisGabriel BenchimolDaniel BalvayLaurence BussieresAnne-Elodie MillischerDavid GréventCécile ButorGihad ChalouhiHouman MahallatiOlivier HélénonBertrand TavitianOlivier ClementYves VilleNathalie SiauveLaurent Julien SalomonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256769 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Benjamin Deloison
Chloé Arthuis
Gabriel Benchimol
Daniel Balvay
Laurence Bussieres
Anne-Elodie Millischer
David Grévent
Cécile Butor
Gihad Chalouhi
Houman Mahallati
Olivier Hélénon
Bertrand Tavitian
Olivier Clement
Yves Ville
Nathalie Siauve
Laurent Julien Salomon
Human placental perfusion measured using dynamic contrast enhancement MRI.
description <h4>Objectives</h4>To evaluate the feasibility of dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and measure values of in vivo placental perfusion in women.<h4>Methods</h4>This study was part of the Placentimage trial (NCT01092949). Gadolinium-chelate (Gd) enhanced dynamic MRI was performed two days before termination of pregnancies at 16 to 34 weeks gestational age (GA). Quantitative analysis was performed using one-compartment intravascular modeling. DCE perfusion parameters were analyzed across GA and were compared in IUGR and AGA fetuses.<h4>Results</h4>134 patients were enrolled. After quality control check, 62 DCE MRI were analyzed including 48 and 14 pregnancies with normal and abnormal karyotypes, respectively. Mean placental blood flow was 129±61 mL/min/100ml in cases with normal karyotypes. Fetuses affected by IUGR (n = 13) showed significantly lower total placental blood flow values than AGA fetuses (n = 35) (F total = 122±88 mL/min versus 259±34 mL/min, p = 0.002). DCE perfusion parameters showed a linear correlation with GA.<h4>Conclusions</h4>Measuring placental perfusion in vivo is possible using DCE MRI. Although this study has many limitations it gives us the first DCE MRI values that provide a potential standard for future research into placental perfusion methods and suggests that placental functional parameters are altered in IUGR pregnancies.
format article
author Benjamin Deloison
Chloé Arthuis
Gabriel Benchimol
Daniel Balvay
Laurence Bussieres
Anne-Elodie Millischer
David Grévent
Cécile Butor
Gihad Chalouhi
Houman Mahallati
Olivier Hélénon
Bertrand Tavitian
Olivier Clement
Yves Ville
Nathalie Siauve
Laurent Julien Salomon
author_facet Benjamin Deloison
Chloé Arthuis
Gabriel Benchimol
Daniel Balvay
Laurence Bussieres
Anne-Elodie Millischer
David Grévent
Cécile Butor
Gihad Chalouhi
Houman Mahallati
Olivier Hélénon
Bertrand Tavitian
Olivier Clement
Yves Ville
Nathalie Siauve
Laurent Julien Salomon
author_sort Benjamin Deloison
title Human placental perfusion measured using dynamic contrast enhancement MRI.
title_short Human placental perfusion measured using dynamic contrast enhancement MRI.
title_full Human placental perfusion measured using dynamic contrast enhancement MRI.
title_fullStr Human placental perfusion measured using dynamic contrast enhancement MRI.
title_full_unstemmed Human placental perfusion measured using dynamic contrast enhancement MRI.
title_sort human placental perfusion measured using dynamic contrast enhancement mri.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/ebaaca519f4f4a029978625e8a9d787a
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