Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients

Libin Zhang, Ping Hu Department of Pharmaceutics, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Yangpu, Shanghai, People’s Republic of China Aim: Pharmacoeconomic cost-effectiveness analysis of two different dosage regimens of levofloxacin in the treatment of acute l...

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Auteurs principaux:	Zhang L, Hu P
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2017
Sujets:	levofloxacin injection capsule sequential therapy minimum cost analysis Geriatrics RC952-954.6
Accès en ligne:	https://doaj.org/article/ebaf7a1f3de949a2a90bdeccb6f7c06a
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spelling	oai:doaj.org-article:ebaf7a1f3de949a2a90bdeccb6f7c06a2021-12-02T07:27:33ZCost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients1178-1998https://doaj.org/article/ebaf7a1f3de949a2a90bdeccb6f7c06a2017-04-01T00:00:00Zhttps://www.dovepress.com/cost-effectiveness-analysis-of-oral-versus-intravenous-drip-infusion-o-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Libin Zhang, Ping Hu Department of Pharmaceutics, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Yangpu, Shanghai, People’s Republic of China Aim: Pharmacoeconomic cost-effectiveness analysis of two different dosage regimens of levofloxacin in the treatment of acute lower respiratory tract infection in elderly patients. Methods: A total of 108 elderly patients with acute lower respiratory tract infection who visited by our hospital between September 2013 and September 2014 were randomly divided into Group A and Group B, with 54 patients in each group. In Group A, levofloxacin injection was given for continuous intravenous infusion treatment, whereas in Group B, levofloxacin injection and levofloxacin capsule were given as sequential therapy (ST). The period of treatment for both the groups was 10 days, and minimum cost analysis was used to analyze the treatment. Results: Groups A and B had cure rates of 61.1% and 59.3% (P>0.05), effective rates of 88.9% and 83.3% (P>0.05), bacterial clearance rates of 96.3% and 92.6% (P>0.05), and incidence rates of adverse reactions of 7.4% and 3.7% (P>0.05), respectively. Treatment costs of Groups A and B were 1,588 RMB and 1,150 RMB, respectively, whereas the cost-effectiveness of the two groups was at 17.86 and 13.81, respectively (P<0.05). Conclusion: Levofloxacin ST had relatively higher cost-effectiveness ratio for the treatment of acute lower respiratory tract infection in elderly patients, especially Chinese. Keywords: Pharmacoeconomic, cost-effectiveness, dosage, elderly patient, treatment cost, ChineseZhang LHu PDove Medical Pressarticlelevofloxacininjectioncapsulesequential therapyminimum cost analysisGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 673-678 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	levofloxacin injection capsule sequential therapy minimum cost analysis Geriatrics RC952-954.6
spellingShingle	levofloxacin injection capsule sequential therapy minimum cost analysis Geriatrics RC952-954.6 Zhang L Hu P Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients
description	Libin Zhang, Ping Hu Department of Pharmaceutics, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Yangpu, Shanghai, People’s Republic of China Aim: Pharmacoeconomic cost-effectiveness analysis of two different dosage regimens of levofloxacin in the treatment of acute lower respiratory tract infection in elderly patients. Methods: A total of 108 elderly patients with acute lower respiratory tract infection who visited by our hospital between September 2013 and September 2014 were randomly divided into Group A and Group B, with 54 patients in each group. In Group A, levofloxacin injection was given for continuous intravenous infusion treatment, whereas in Group B, levofloxacin injection and levofloxacin capsule were given as sequential therapy (ST). The period of treatment for both the groups was 10 days, and minimum cost analysis was used to analyze the treatment. Results: Groups A and B had cure rates of 61.1% and 59.3% (P>0.05), effective rates of 88.9% and 83.3% (P>0.05), bacterial clearance rates of 96.3% and 92.6% (P>0.05), and incidence rates of adverse reactions of 7.4% and 3.7% (P>0.05), respectively. Treatment costs of Groups A and B were 1,588 RMB and 1,150 RMB, respectively, whereas the cost-effectiveness of the two groups was at 17.86 and 13.81, respectively (P<0.05). Conclusion: Levofloxacin ST had relatively higher cost-effectiveness ratio for the treatment of acute lower respiratory tract infection in elderly patients, especially Chinese. Keywords: Pharmacoeconomic, cost-effectiveness, dosage, elderly patient, treatment cost, Chinese
format	article
author	Zhang L Hu P
author_facet	Zhang L Hu P
author_sort	Zhang L
title	Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients
title_short	Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients
title_full	Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients
title_fullStr	Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients
title_full_unstemmed	Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients
title_sort	cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in chinese elderly patients
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/ebaf7a1f3de949a2a90bdeccb6f7c06a
work_keys_str_mv	AT zhangl costeffectivenessanalysisoforalversusintravenousdripinfusionoflevofloxacininthetreatmentofacutelowerrespiratorytractinfectioninchineseelderlypatients AT hup costeffectivenessanalysisoforalversusintravenousdripinfusionoflevofloxacininthetreatmentofacutelowerrespiratorytractinfectioninchineseelderlypatients
_version_	1718399434149068800

Cost-effectiveness analysis of oral versus intravenous drip infusion of levofloxacin in the treatment of acute lower respiratory tract infection in Chinese elderly patients

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