Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma

Background: Gastric carcinoma (GC) is a molecularly and phenotypically highly heterogeneous disease, making the prognostic prediction challenging. On the other hand, Inflammation as part of the active cross-talk between the tumor and the host in the tumor or its microenvironment could affect prognos...

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Autores principales:	ShuQiao Zhang, XinYu Li, ChunZhi Tang, WeiHong Kuang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gastric carcinoma (GC) inflammation lncRNAs long non-coding RNAs prognosis (carcinoma) immune infiltration Genetics QH426-470
Acceso en línea:	https://doaj.org/article/ebb4de31b01f48c381e636b1429c217e
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spelling	oai:doaj.org-article:ebb4de31b01f48c381e636b1429c217e2021-11-08T11:39:53ZInflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma1664-802110.3389/fgene.2021.736766https://doaj.org/article/ebb4de31b01f48c381e636b1429c217e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.736766/fullhttps://doaj.org/toc/1664-8021Background: Gastric carcinoma (GC) is a molecularly and phenotypically highly heterogeneous disease, making the prognostic prediction challenging. On the other hand, Inflammation as part of the active cross-talk between the tumor and the host in the tumor or its microenvironment could affect prognosis.Method: We established a prognostic multi lncRNAs signature that could better predict the prognosis of GC patients based on inflammation-related differentially expressed lncRNAs in GC.Results: We identified 10 differently expressed lncRNAs related to inflammation associated with GC prognosis. Kaplan-Meier survival analysis demonstrated that high-risk inflammation-related lncRNAs signature was related to poor prognosis of GC. Moreover, the inflammation-related lncRNAs signature had an AUC of 0.788, proving their utility in predicting GC prognosis. Indeed, our risk signature is more precise in predicting the prognosis of GC patients than traditional clinicopathological manifestations. Immune and tumor-related pathways for individuals in the low and high-risk groups were further revealed by GSEA. Moreover, TCGA based analysis revealed significant differences in HLA, MHC class-I, cytolytic activity, parainflammation, co-stimulation of APC, type II INF response, and type I INF response between the two risk groups. Immune checkpoints revealed CD86, TNFSF18, CD200, and LAIR1 were differently expressed between lowand high-risk groups.Conclusion: A novel inflammation-related lncRNAs (AC015660.1, LINC01094, AL512506.1, AC124067.2, AC016737.1, AL136115.1, AP000695.1, AC104695.3, LINC00449, AC090772.1) signature may provide insight into the new therapies and prognosis prediction for GC patients.ShuQiao ZhangXinYu LiChunZhi TangWeiHong KuangFrontiers Media S.A.articlegastric carcinoma (GC)inflammationlncRNAslong non-coding RNAsprognosis (carcinoma)immune infiltrationGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric carcinoma (GC) inflammation lncRNAs long non-coding RNAs prognosis (carcinoma) immune infiltration Genetics QH426-470
spellingShingle	gastric carcinoma (GC) inflammation lncRNAs long non-coding RNAs prognosis (carcinoma) immune infiltration Genetics QH426-470 ShuQiao Zhang XinYu Li ChunZhi Tang WeiHong Kuang Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma
description	Background: Gastric carcinoma (GC) is a molecularly and phenotypically highly heterogeneous disease, making the prognostic prediction challenging. On the other hand, Inflammation as part of the active cross-talk between the tumor and the host in the tumor or its microenvironment could affect prognosis.Method: We established a prognostic multi lncRNAs signature that could better predict the prognosis of GC patients based on inflammation-related differentially expressed lncRNAs in GC.Results: We identified 10 differently expressed lncRNAs related to inflammation associated with GC prognosis. Kaplan-Meier survival analysis demonstrated that high-risk inflammation-related lncRNAs signature was related to poor prognosis of GC. Moreover, the inflammation-related lncRNAs signature had an AUC of 0.788, proving their utility in predicting GC prognosis. Indeed, our risk signature is more precise in predicting the prognosis of GC patients than traditional clinicopathological manifestations. Immune and tumor-related pathways for individuals in the low and high-risk groups were further revealed by GSEA. Moreover, TCGA based analysis revealed significant differences in HLA, MHC class-I, cytolytic activity, parainflammation, co-stimulation of APC, type II INF response, and type I INF response between the two risk groups. Immune checkpoints revealed CD86, TNFSF18, CD200, and LAIR1 were differently expressed between lowand high-risk groups.Conclusion: A novel inflammation-related lncRNAs (AC015660.1, LINC01094, AL512506.1, AC124067.2, AC016737.1, AL136115.1, AP000695.1, AC104695.3, LINC00449, AC090772.1) signature may provide insight into the new therapies and prognosis prediction for GC patients.
format	article
author	ShuQiao Zhang XinYu Li ChunZhi Tang WeiHong Kuang
author_facet	ShuQiao Zhang XinYu Li ChunZhi Tang WeiHong Kuang
author_sort	ShuQiao Zhang
title	Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma
title_short	Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma
title_full	Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma
title_fullStr	Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma
title_full_unstemmed	Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma
title_sort	inflammation-related long non-coding rna signature predicts the prognosis of gastric carcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ebb4de31b01f48c381e636b1429c217e
work_keys_str_mv	AT shuqiaozhang inflammationrelatedlongnoncodingrnasignaturepredictstheprognosisofgastriccarcinoma AT xinyuli inflammationrelatedlongnoncodingrnasignaturepredictstheprognosisofgastriccarcinoma AT chunzhitang inflammationrelatedlongnoncodingrnasignaturepredictstheprognosisofgastriccarcinoma AT weihongkuang inflammationrelatedlongnoncodingrnasignaturepredictstheprognosisofgastriccarcinoma
_version_	1718442292188020736

Inflammation-Related Long Non-Coding RNA Signature Predicts the Prognosis of Gastric Carcinoma

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