Association of a Total Cholesterol Polygenic Score with Cholesterol Levels and Pathological Biomarkers across the Alzheimer’s Disease Spectrum

Association of a Total Cholesterol Polygenic Score with Cholesterol Levels and Pathological Biomarkers across the Alzheimer’s Disease Spectrum

Midlife hypercholesterolemia is a well-known risk factor for sporadic Alzheimer’s disease (AD), and like AD, it is highly influenced by genetics with heritability estimates of 32–63%. We thus hypothesized that genetics underlying peripheral blood total cholesterol (TC) levels could influence the ris...

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Autores principales: Nathalie I. V. Nilsson, Cynthia Picard, Anne Labonté, Theresa Köbe, Pierre-François Meyer, Sylvia Villeneuve, Daniel Auld, Judes Poirier, for the PREVENT-AD Research Group, Alzheimer’s Disease Neuroimaging Initiative
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
polygenic score
Alzheimer’s disease
cholesterol
amyloid
tau protein
aging
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/ebb65cee29624861a4bf683fb670e657
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