Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and in vivo by blocking chemotherapy-induced ER stress.

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexia Karen Cotte, Virginie Aires, Maxime Fredon, Emeric Limagne, Valentin Derangère, Marion Thibaudin, Etienne Humblin, Alessandra Scagliarini, Jean-Paul Pais de Barros, Patrick Hillon, François Ghiringhelli, Dominique Delmas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ebbb44a3f0364d6cb5aecb457ae581a2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ebbb44a3f0364d6cb5aecb457ae581a2
record_format	dspace
spelling	oai:doaj.org-article:ebbb44a3f0364d6cb5aecb457ae581a22021-12-02T15:34:40ZLysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance10.1038/s41467-017-02732-52041-1723https://doaj.org/article/ebbb44a3f0364d6cb5aecb457ae581a22018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02732-5https://doaj.org/toc/2041-1723Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and in vivo by blocking chemotherapy-induced ER stress.Alexia Karen CotteVirginie AiresMaxime FredonEmeric LimagneValentin DerangèreMarion ThibaudinEtienne HumblinAlessandra ScagliariniJean-Paul Pais de BarrosPatrick HillonFrançois GhiringhelliDominique DelmasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexia Karen Cotte Virginie Aires Maxime Fredon Emeric Limagne Valentin Derangère Marion Thibaudin Etienne Humblin Alessandra Scagliarini Jean-Paul Pais de Barros Patrick Hillon François Ghiringhelli Dominique Delmas Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
description	Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and in vivo by blocking chemotherapy-induced ER stress.
format	article
author	Alexia Karen Cotte Virginie Aires Maxime Fredon Emeric Limagne Valentin Derangère Marion Thibaudin Etienne Humblin Alessandra Scagliarini Jean-Paul Pais de Barros Patrick Hillon François Ghiringhelli Dominique Delmas
author_facet	Alexia Karen Cotte Virginie Aires Maxime Fredon Emeric Limagne Valentin Derangère Marion Thibaudin Etienne Humblin Alessandra Scagliarini Jean-Paul Pais de Barros Patrick Hillon François Ghiringhelli Dominique Delmas
author_sort	Alexia Karen Cotte
title	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
title_short	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
title_full	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
title_fullStr	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
title_full_unstemmed	Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
title_sort	lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ebbb44a3f0364d6cb5aecb457ae581a2
work_keys_str_mv	AT alexiakarencotte lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT virginieaires lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT maximefredon lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT emericlimagne lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT valentinderangere lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT marionthibaudin lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT etiennehumblin lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT alessandrascagliarini lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT jeanpaulpaisdebarros lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT patrickhillon lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT francoisghiringhelli lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance AT dominiquedelmas lysophosphatidylcholineacyltransferase2mediatedlipiddropletproductionsupportscolorectalcancerchemoresistance
_version_	1718386813855334400

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

Ejemplares similares