Control of type 2 diabetes mellitus: problems and prospects for their solution

Important medico-social and economic implications of type 2 diabetes mellitus (DM2) are determined by its continuously growing prevalence, frequencyand severity of complications related to inadequate glycemic control. Large-scale studies (UKPDS, VADT, ACCORD, ADVANCE) havedemonstrated controversial...

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Autores principales:	Tatiana Ivanovna Romantsova, Irina Vladimirovna Glinkina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	type 2 diabetes mellitus postprandial glycemia dpp-iv inhibitors Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/ebc3e71c7bb745a0bb455a04eded1eed
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spelling	oai:doaj.org-article:ebc3e71c7bb745a0bb455a04eded1eed2021-11-14T09:00:14ZControl of type 2 diabetes mellitus: problems and prospects for their solution2072-03512072-037810.14341/2072-0351-5703https://doaj.org/article/ebc3e71c7bb745a0bb455a04eded1eed2009-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5703https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Important medico-social and economic implications of type 2 diabetes mellitus (DM2) are determined by its continuously growing prevalence, frequencyand severity of complications related to inadequate glycemic control. Large-scale studies (UKPDS, VADT, ACCORD, ADVANCE) havedemonstrated controversial effect of intensive glycemic control (estimated from HbA1c dynamics) on diabetic macrovascular complication. At thesame time, epidemiological, experimental, and observational studies yielded conclusive evidence of postprandial glycemia (PPG) contribution tooverall glycemic control and its role in the development of macrovascular complications. For this reason, PPG control is currently given as much attentionas traditional parameters (HbA1c and fasting glycemia). Dipeptidyl peptidase-IV (DPP-IV) inhibitors are a new class of hypoglycemic agentsthat raise levels of incretins, glucagons-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in blood by suppressing DPPIVactivity. The resulting recovery of physiological insulin secretion promotes reduction of fasting and postprandial glycemia and HbA1c level.Tatiana Ivanovna RomantsovaIrina Vladimirovna GlinkinaEndocrinology Research Centrearticletype 2 diabetes mellituspostprandial glycemiadpp-iv inhibitorsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 4, Pp 42-46 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus postprandial glycemia dpp-iv inhibitors Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus postprandial glycemia dpp-iv inhibitors Nutritional diseases. Deficiency diseases RC620-627 Tatiana Ivanovna Romantsova Irina Vladimirovna Glinkina Control of type 2 diabetes mellitus: problems and prospects for their solution
description	Important medico-social and economic implications of type 2 diabetes mellitus (DM2) are determined by its continuously growing prevalence, frequencyand severity of complications related to inadequate glycemic control. Large-scale studies (UKPDS, VADT, ACCORD, ADVANCE) havedemonstrated controversial effect of intensive glycemic control (estimated from HbA1c dynamics) on diabetic macrovascular complication. At thesame time, epidemiological, experimental, and observational studies yielded conclusive evidence of postprandial glycemia (PPG) contribution tooverall glycemic control and its role in the development of macrovascular complications. For this reason, PPG control is currently given as much attentionas traditional parameters (HbA1c and fasting glycemia). Dipeptidyl peptidase-IV (DPP-IV) inhibitors are a new class of hypoglycemic agentsthat raise levels of incretins, glucagons-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in blood by suppressing DPPIVactivity. The resulting recovery of physiological insulin secretion promotes reduction of fasting and postprandial glycemia and HbA1c level.
format	article
author	Tatiana Ivanovna Romantsova Irina Vladimirovna Glinkina
author_facet	Tatiana Ivanovna Romantsova Irina Vladimirovna Glinkina
author_sort	Tatiana Ivanovna Romantsova
title	Control of type 2 diabetes mellitus: problems and prospects for their solution
title_short	Control of type 2 diabetes mellitus: problems and prospects for their solution
title_full	Control of type 2 diabetes mellitus: problems and prospects for their solution
title_fullStr	Control of type 2 diabetes mellitus: problems and prospects for their solution
title_full_unstemmed	Control of type 2 diabetes mellitus: problems and prospects for their solution
title_sort	control of type 2 diabetes mellitus: problems and prospects for their solution
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/ebc3e71c7bb745a0bb455a04eded1eed
work_keys_str_mv	AT tatianaivanovnaromantsova controloftype2diabetesmellitusproblemsandprospectsfortheirsolution AT irinavladimirovnaglinkina controloftype2diabetesmellitusproblemsandprospectsfortheirsolution
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Control of type 2 diabetes mellitus: problems and prospects for their solution

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