Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement

Ventral tegmental area (VTA) is involved in reward behaviours, but the precise contribution of VTA glutamatergic neurons to this process is not known. Here the authors show that phasic but not sustained optogenetic stimulation of VTA glutamatergic neurons is rewarding and involves co-release of GABA...

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Autores principales: Ji Hoon Yoo, Vivien Zell, Navarre Gutierrez-Reed, Johnathan Wu, Reed Ressler, Mohammad Ali Shenasa, Alexander B. Johnson, Kathryn H. Fife, Lauren Faget, Thomas S. Hnasko
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/ebc4106e19444eaba72aa7e6cdab8f51
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Sumario:Ventral tegmental area (VTA) is involved in reward behaviours, but the precise contribution of VTA glutamatergic neurons to this process is not known. Here the authors show that phasic but not sustained optogenetic stimulation of VTA glutamatergic neurons is rewarding and involves co-release of GABA.