Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement

Ventral tegmental area (VTA) is involved in reward behaviours, but the precise contribution of VTA glutamatergic neurons to this process is not known. Here the authors show that phasic but not sustained optogenetic stimulation of VTA glutamatergic neurons is rewarding and involves co-release of GABA...

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Autores principales:	Ji Hoon Yoo, Vivien Zell, Navarre Gutierrez-Reed, Johnathan Wu, Reed Ressler, Mohammad Ali Shenasa, Alexander B. Johnson, Kathryn H. Fife, Lauren Faget, Thomas S. Hnasko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ebc4106e19444eaba72aa7e6cdab8f51
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spelling	oai:doaj.org-article:ebc4106e19444eaba72aa7e6cdab8f512021-12-02T15:35:00ZVentral tegmental area glutamate neurons co-release GABA and promote positive reinforcement10.1038/ncomms136972041-1723https://doaj.org/article/ebc4106e19444eaba72aa7e6cdab8f512016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13697https://doaj.org/toc/2041-1723Ventral tegmental area (VTA) is involved in reward behaviours, but the precise contribution of VTA glutamatergic neurons to this process is not known. Here the authors show that phasic but not sustained optogenetic stimulation of VTA glutamatergic neurons is rewarding and involves co-release of GABA.Ji Hoon YooVivien ZellNavarre Gutierrez-ReedJohnathan WuReed ResslerMohammad Ali ShenasaAlexander B. JohnsonKathryn H. FifeLauren FagetThomas S. HnaskoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji Hoon Yoo Vivien Zell Navarre Gutierrez-Reed Johnathan Wu Reed Ressler Mohammad Ali Shenasa Alexander B. Johnson Kathryn H. Fife Lauren Faget Thomas S. Hnasko Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
description	Ventral tegmental area (VTA) is involved in reward behaviours, but the precise contribution of VTA glutamatergic neurons to this process is not known. Here the authors show that phasic but not sustained optogenetic stimulation of VTA glutamatergic neurons is rewarding and involves co-release of GABA.
format	article
author	Ji Hoon Yoo Vivien Zell Navarre Gutierrez-Reed Johnathan Wu Reed Ressler Mohammad Ali Shenasa Alexander B. Johnson Kathryn H. Fife Lauren Faget Thomas S. Hnasko
author_facet	Ji Hoon Yoo Vivien Zell Navarre Gutierrez-Reed Johnathan Wu Reed Ressler Mohammad Ali Shenasa Alexander B. Johnson Kathryn H. Fife Lauren Faget Thomas S. Hnasko
author_sort	Ji Hoon Yoo
title	Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
title_short	Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
title_full	Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
title_fullStr	Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
title_full_unstemmed	Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement
title_sort	ventral tegmental area glutamate neurons co-release gaba and promote positive reinforcement
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ebc4106e19444eaba72aa7e6cdab8f51
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Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement

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