Tetrabenazine-induced oculogyric crisis – a rare complication in the treatment of Gilles de la Tourette syndrome
Piotr Janik,1 Monika Figura1,2 1Department of Neurology, Anna Gostynska Wolski Hospital, 2Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland Abstract: Tetrabenazine is used in the treatment of chorea, tardive dyskinesia, tics, and dystonia. It rarely...
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Dove Medical Press
2016
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oai:doaj.org-article:ebd016ef25124500bb1a55c763cd3c112021-12-02T06:35:07ZTetrabenazine-induced oculogyric crisis – a rare complication in the treatment of Gilles de la Tourette syndrome1178-2021https://doaj.org/article/ebd016ef25124500bb1a55c763cd3c112016-02-01T00:00:00Zhttps://www.dovepress.com/tetrabenazine-induced-oculogyric-crisis-ndash-a-rare-complication-in-t-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Piotr Janik,1 Monika Figura1,2 1Department of Neurology, Anna Gostynska Wolski Hospital, 2Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland Abstract: Tetrabenazine is used in the treatment of chorea, tardive dyskinesia, tics, and dystonia. It rarely causes acute eyeball dystonia and the description of this complication in Gilles de la Tourette syndrome is limited. We provide a description of an acute oculogyric crisis caused by tetrabenazine in a patient with severe tics. The patient had never developed acute dystonic reactions, although he was previously exposed to numerous dopamine receptor-blocking agents. After 8 days of therapy with tetrabenazine at a dose of 62.5 mg daily, the patient developed involuntary movement of the eyeballs. Withdrawal of tetrabenazine caused resolution of all symptoms after a week. The purpose of this description is to draw attention to the potential of tetrabenazine to induce acute oculogyric crisis as well as the difficulty of differentiating drug-induced dystonia from dystonic tics in patients with Gilles de la Tourette syndrome. Keywords: acute dyskinesia, dystonic tics, eyeball dystonia, drug-induced dystonia, tic disorder, tetrabenazine-induced side effectsJanik PFigura MDove Medical PressarticleTetrabenazineoculogyric crisisTourette syndromeacute dystoniadystonic tics.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 497-499 (2016) |
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Tetrabenazine oculogyric crisis Tourette syndrome acute dystonia dystonic tics. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Tetrabenazine oculogyric crisis Tourette syndrome acute dystonia dystonic tics. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Janik P Figura M Tetrabenazine-induced oculogyric crisis – a rare complication in the treatment of Gilles de la Tourette syndrome |
| description |
Piotr Janik,1 Monika Figura1,2 1Department of Neurology, Anna Gostynska Wolski Hospital, 2Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland Abstract: Tetrabenazine is used in the treatment of chorea, tardive dyskinesia, tics, and dystonia. It rarely causes acute eyeball dystonia and the description of this complication in Gilles de la Tourette syndrome is limited. We provide a description of an acute oculogyric crisis caused by tetrabenazine in a patient with severe tics. The patient had never developed acute dystonic reactions, although he was previously exposed to numerous dopamine receptor-blocking agents. After 8 days of therapy with tetrabenazine at a dose of 62.5 mg daily, the patient developed involuntary movement of the eyeballs. Withdrawal of tetrabenazine caused resolution of all symptoms after a week. The purpose of this description is to draw attention to the potential of tetrabenazine to induce acute oculogyric crisis as well as the difficulty of differentiating drug-induced dystonia from dystonic tics in patients with Gilles de la Tourette syndrome. Keywords: acute dyskinesia, dystonic tics, eyeball dystonia, drug-induced dystonia, tic disorder, tetrabenazine-induced side effects |
| format |
article |
| author |
Janik P Figura M |
| author_facet |
Janik P Figura M |
| author_sort |
Janik P |
| title |
Tetrabenazine-induced oculogyric crisis – a rare complication in the treatment of Gilles de la Tourette syndrome |
| title_short |
Tetrabenazine-induced oculogyric crisis – a rare complication in the treatment of Gilles de la Tourette syndrome |
| title_full |
Tetrabenazine-induced oculogyric crisis – a rare complication in the treatment of Gilles de la Tourette syndrome |
| title_fullStr |
Tetrabenazine-induced oculogyric crisis – a rare complication in the treatment of Gilles de la Tourette syndrome |
| title_full_unstemmed |
Tetrabenazine-induced oculogyric crisis – a rare complication in the treatment of Gilles de la Tourette syndrome |
| title_sort |
tetrabenazine-induced oculogyric crisis – a rare complication in the treatment of gilles de la tourette syndrome |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/ebd016ef25124500bb1a55c763cd3c11 |
| work_keys_str_mv |
AT janikp tetrabenazineinducedoculogyriccrisisndashararecomplicationinthetreatmentofgillesdelatourettesyndrome AT figuram tetrabenazineinducedoculogyriccrisisndashararecomplicationinthetreatmentofgillesdelatourettesyndrome |
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