Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa

Abstract Lophotrochozoan species exhibit wide morphological diversity; however, the molecular basis underlying this diversity remains unclear. Here, we explored the evolution of Notch pathway genes across 37 metazoan species via phylogenetic and molecular evolutionary studies with emphasis on the lo...

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Autores principales:	Xin He, Fucun Wu, Linlin Zhang, Li Li, Guofan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ebd2a54d9da5459fa034b44822e233c6
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spelling	oai:doaj.org-article:ebd2a54d9da5459fa034b44822e233c62021-12-02T15:56:42ZComparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa10.1038/s41598-021-90800-82045-2322https://doaj.org/article/ebd2a54d9da5459fa034b44822e233c62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90800-8https://doaj.org/toc/2045-2322Abstract Lophotrochozoan species exhibit wide morphological diversity; however, the molecular basis underlying this diversity remains unclear. Here, we explored the evolution of Notch pathway genes across 37 metazoan species via phylogenetic and molecular evolutionary studies with emphasis on the lophotrochozoans. We displayed the components of Notch pathway in metazoans and found that Delta and Hes/Hey-related genes, as well as their functional domains, are duplicated in lophotrochozoans. Comparative transcriptomics analyses allow us to pinpoint sequence divergence of multigene families in the Notch signalling pathway. We identified the duplication mechanism of a mollusc-specific gene, Delta2, and found it displayed complementary expression throughout development. Furthermore, we found the functional diversification not only in expanded genes in the Notch pathway (Delta and Hes/Hey-related genes), but also in evolutionary conservative genes (Notch, Presenilin, and Su(H)). Together, this comprehensive study demonstrates conservation and divergence within the Notch pathway, reveals evolutionary relationships among metazoans, and provides evidence for the occurrence of developmental diversity in lophotrochozoans, as well as a basis for future gene function studies.Xin HeFucun WuLinlin ZhangLi LiGuofan ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin He Fucun Wu Linlin Zhang Li Li Guofan Zhang Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa
description	Abstract Lophotrochozoan species exhibit wide morphological diversity; however, the molecular basis underlying this diversity remains unclear. Here, we explored the evolution of Notch pathway genes across 37 metazoan species via phylogenetic and molecular evolutionary studies with emphasis on the lophotrochozoans. We displayed the components of Notch pathway in metazoans and found that Delta and Hes/Hey-related genes, as well as their functional domains, are duplicated in lophotrochozoans. Comparative transcriptomics analyses allow us to pinpoint sequence divergence of multigene families in the Notch signalling pathway. We identified the duplication mechanism of a mollusc-specific gene, Delta2, and found it displayed complementary expression throughout development. Furthermore, we found the functional diversification not only in expanded genes in the Notch pathway (Delta and Hes/Hey-related genes), but also in evolutionary conservative genes (Notch, Presenilin, and Su(H)). Together, this comprehensive study demonstrates conservation and divergence within the Notch pathway, reveals evolutionary relationships among metazoans, and provides evidence for the occurrence of developmental diversity in lophotrochozoans, as well as a basis for future gene function studies.
format	article
author	Xin He Fucun Wu Linlin Zhang Li Li Guofan Zhang
author_facet	Xin He Fucun Wu Linlin Zhang Li Li Guofan Zhang
author_sort	Xin He
title	Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa
title_short	Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa
title_full	Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa
title_fullStr	Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa
title_full_unstemmed	Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa
title_sort	comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ebd2a54d9da5459fa034b44822e233c6
work_keys_str_mv	AT xinhe comparativeandevolutionaryanalysesrevealconservationanddivergenceofthenotchpathwayinlophotrochozoa AT fucunwu comparativeandevolutionaryanalysesrevealconservationanddivergenceofthenotchpathwayinlophotrochozoa AT linlinzhang comparativeandevolutionaryanalysesrevealconservationanddivergenceofthenotchpathwayinlophotrochozoa AT lili comparativeandevolutionaryanalysesrevealconservationanddivergenceofthenotchpathwayinlophotrochozoa AT guofanzhang comparativeandevolutionaryanalysesrevealconservationanddivergenceofthenotchpathwayinlophotrochozoa
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Comparative and evolutionary analyses reveal conservation and divergence of the notch pathway in lophotrochozoa

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