Genetic risk factors for colorectal cancer in multiethnic Indonesians

Abstract Colorectal cancer is a common cancer in Indonesia, yet it has been understudied in this resource-constrained setting. We conducted a genome-wide association study focused on evaluation and preliminary discovery of colorectal cancer risk factors in Indonesians. We administered detailed quest...

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Autores principales:	Irawan Yusuf, Bens Pardamean, James W. Baurley, Arif Budiarto, Upik A. Miskad, Ronald E. Lusikooy, Arham Arsyad, Akram Irwan, George Mathew, Ivet Suriapranata, Rinaldy Kusuma, Muhamad F. Kacamarga, Tjeng W. Cenggoro, Christopher McMahan, Chase Joyner, Carissa I. Pardamean
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ebd70b4c53f14791b8daf94f7e578a93
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spelling	oai:doaj.org-article:ebd70b4c53f14791b8daf94f7e578a932021-12-02T17:02:13ZGenetic risk factors for colorectal cancer in multiethnic Indonesians10.1038/s41598-021-88805-42045-2322https://doaj.org/article/ebd70b4c53f14791b8daf94f7e578a932021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88805-4https://doaj.org/toc/2045-2322Abstract Colorectal cancer is a common cancer in Indonesia, yet it has been understudied in this resource-constrained setting. We conducted a genome-wide association study focused on evaluation and preliminary discovery of colorectal cancer risk factors in Indonesians. We administered detailed questionnaires and collecting blood samples from 162 colorectal cancer cases throughout Makassar, Indonesia. We also established a control set of 193 healthy individuals frequency matched by age, sex, and ethnicity. A genome-wide association analysis was performed on 84 cases and 89 controls passing quality control. We evaluated known colorectal cancer genetic variants using logistic regression and established a genome-wide polygenic risk model using a Bayesian variable selection technique. We replicate associations for rs9497673, rs6936461 and rs7758229 on chromosome 6; rs11255841 on chromosome 10; and rs4779584, rs11632715, and rs73376930 on chromosome 15. Polygenic modeling identified 10 SNP associated with colorectal cancer risk. This work helps characterize the relationship between variants in the SCL22A3, SCG5, GREM1, and STXBP5-AS1 genes and colorectal cancer in a diverse Indonesian population. With further biobanking and international research collaborations, variants specific to colorectal cancer risk in Indonesians will be identified.Irawan YusufBens PardameanJames W. BaurleyArif BudiartoUpik A. MiskadRonald E. LusikooyArham ArsyadAkram IrwanGeorge MathewIvet SuriapranataRinaldy KusumaMuhamad F. KacamargaTjeng W. CenggoroChristopher McMahanChase JoynerCarissa I. PardameanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irawan Yusuf Bens Pardamean James W. Baurley Arif Budiarto Upik A. Miskad Ronald E. Lusikooy Arham Arsyad Akram Irwan George Mathew Ivet Suriapranata Rinaldy Kusuma Muhamad F. Kacamarga Tjeng W. Cenggoro Christopher McMahan Chase Joyner Carissa I. Pardamean Genetic risk factors for colorectal cancer in multiethnic Indonesians
description	Abstract Colorectal cancer is a common cancer in Indonesia, yet it has been understudied in this resource-constrained setting. We conducted a genome-wide association study focused on evaluation and preliminary discovery of colorectal cancer risk factors in Indonesians. We administered detailed questionnaires and collecting blood samples from 162 colorectal cancer cases throughout Makassar, Indonesia. We also established a control set of 193 healthy individuals frequency matched by age, sex, and ethnicity. A genome-wide association analysis was performed on 84 cases and 89 controls passing quality control. We evaluated known colorectal cancer genetic variants using logistic regression and established a genome-wide polygenic risk model using a Bayesian variable selection technique. We replicate associations for rs9497673, rs6936461 and rs7758229 on chromosome 6; rs11255841 on chromosome 10; and rs4779584, rs11632715, and rs73376930 on chromosome 15. Polygenic modeling identified 10 SNP associated with colorectal cancer risk. This work helps characterize the relationship between variants in the SCL22A3, SCG5, GREM1, and STXBP5-AS1 genes and colorectal cancer in a diverse Indonesian population. With further biobanking and international research collaborations, variants specific to colorectal cancer risk in Indonesians will be identified.
format	article
author	Irawan Yusuf Bens Pardamean James W. Baurley Arif Budiarto Upik A. Miskad Ronald E. Lusikooy Arham Arsyad Akram Irwan George Mathew Ivet Suriapranata Rinaldy Kusuma Muhamad F. Kacamarga Tjeng W. Cenggoro Christopher McMahan Chase Joyner Carissa I. Pardamean
author_facet	Irawan Yusuf Bens Pardamean James W. Baurley Arif Budiarto Upik A. Miskad Ronald E. Lusikooy Arham Arsyad Akram Irwan George Mathew Ivet Suriapranata Rinaldy Kusuma Muhamad F. Kacamarga Tjeng W. Cenggoro Christopher McMahan Chase Joyner Carissa I. Pardamean
author_sort	Irawan Yusuf
title	Genetic risk factors for colorectal cancer in multiethnic Indonesians
title_short	Genetic risk factors for colorectal cancer in multiethnic Indonesians
title_full	Genetic risk factors for colorectal cancer in multiethnic Indonesians
title_fullStr	Genetic risk factors for colorectal cancer in multiethnic Indonesians
title_full_unstemmed	Genetic risk factors for colorectal cancer in multiethnic Indonesians
title_sort	genetic risk factors for colorectal cancer in multiethnic indonesians
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ebd70b4c53f14791b8daf94f7e578a93
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Genetic risk factors for colorectal cancer in multiethnic Indonesians

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