Imaging mitochondrial flux in single cells with a FRET sensor for pyruvate.

Imaging mitochondrial flux in single cells with a FRET sensor for pyruvate.

Mitochondrial flux is currently accessible at low resolution. Here we introduce a genetically-encoded FRET sensor for pyruvate, and methods for quantitative measurement of pyruvate transport, pyruvate production and mitochondrial pyruvate consumption in intact individual cells at high temporal resol...

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Autores principales: Alejandro San Martín, Sebastián Ceballo, Felipe Baeza-Lehnert, Rodrigo Lerchundi, Rocío Valdebenito, Yasna Contreras-Baeza, Karin Alegría, L Felipe Barros
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ebd763472cc34e4aa49c19ddf4e6e2bb
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