Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish

The molecular mechanism regulating macrophage interaction with endothelial cells during development is unclear. Here, the authors show that in zebrafish mutation of hypoxia-inducible factor-1α impairs macrophage mobilization from the aorta-gonad-mesonephros, causing defects in angiogenesis and vesse...

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Autores principales:	Claudia Gerri, Rubén Marín-Juez, Michele Marass, Alora Marks, Hans-Martin Maischein, Didier Y R. Stainier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ebd77d3a46e14354b42078d1b9cafcf1
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spelling	oai:doaj.org-article:ebd77d3a46e14354b42078d1b9cafcf12021-12-02T17:06:16ZHif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish10.1038/ncomms154922041-1723https://doaj.org/article/ebd77d3a46e14354b42078d1b9cafcf12017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15492https://doaj.org/toc/2041-1723The molecular mechanism regulating macrophage interaction with endothelial cells during development is unclear. Here, the authors show that in zebrafish mutation of hypoxia-inducible factor-1α impairs macrophage mobilization from the aorta-gonad-mesonephros, causing defects in angiogenesis and vessel repair.Claudia GerriRubén Marín-JuezMichele MarassAlora MarksHans-Martin MaischeinDidier Y R. StainierNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Claudia Gerri Rubén Marín-Juez Michele Marass Alora Marks Hans-Martin Maischein Didier Y R. Stainier Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
description	The molecular mechanism regulating macrophage interaction with endothelial cells during development is unclear. Here, the authors show that in zebrafish mutation of hypoxia-inducible factor-1α impairs macrophage mobilization from the aorta-gonad-mesonephros, causing defects in angiogenesis and vessel repair.
format	article
author	Claudia Gerri Rubén Marín-Juez Michele Marass Alora Marks Hans-Martin Maischein Didier Y R. Stainier
author_facet	Claudia Gerri Rubén Marín-Juez Michele Marass Alora Marks Hans-Martin Maischein Didier Y R. Stainier
author_sort	Claudia Gerri
title	Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
title_short	Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
title_full	Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
title_fullStr	Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
title_full_unstemmed	Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
title_sort	hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ebd77d3a46e14354b42078d1b9cafcf1
work_keys_str_mv	AT claudiagerri hif1aregulatesmacrophageendothelialinteractionsduringbloodvesseldevelopmentinzebrafish AT rubenmarinjuez hif1aregulatesmacrophageendothelialinteractionsduringbloodvesseldevelopmentinzebrafish AT michelemarass hif1aregulatesmacrophageendothelialinteractionsduringbloodvesseldevelopmentinzebrafish AT aloramarks hif1aregulatesmacrophageendothelialinteractionsduringbloodvesseldevelopmentinzebrafish AT hansmartinmaischein hif1aregulatesmacrophageendothelialinteractionsduringbloodvesseldevelopmentinzebrafish AT didieryrstainier hif1aregulatesmacrophageendothelialinteractionsduringbloodvesseldevelopmentinzebrafish
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Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish

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