An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin

The interaction of long circulating drugs with biological molecules might trigger harmful side effects. Here, the authors design an anticoagulant compound that can be deactivatedin vivo using click chemistry, paving the way to the design of drugs with tunable in vivoproperties.

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Autores principales:	Sylvain Ursuegui, Marion Recher, Wojciech Krężel, Alain Wagner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ebda2b9fe32443d9b94c7789c9666492
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spelling	oai:doaj.org-article:ebda2b9fe32443d9b94c7789c96664922021-12-02T14:42:51ZAn in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin10.1038/ncomms152422041-1723https://doaj.org/article/ebda2b9fe32443d9b94c7789c96664922017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15242https://doaj.org/toc/2041-1723The interaction of long circulating drugs with biological molecules might trigger harmful side effects. Here, the authors design an anticoagulant compound that can be deactivatedin vivo using click chemistry, paving the way to the design of drugs with tunable in vivoproperties.Sylvain UrsueguiMarion RecherWojciech KrężelAlain WagnerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sylvain Ursuegui Marion Recher Wojciech Krężel Alain Wagner An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
description	The interaction of long circulating drugs with biological molecules might trigger harmful side effects. Here, the authors design an anticoagulant compound that can be deactivatedin vivo using click chemistry, paving the way to the design of drugs with tunable in vivoproperties.
format	article
author	Sylvain Ursuegui Marion Recher Wojciech Krężel Alain Wagner
author_facet	Sylvain Ursuegui Marion Recher Wojciech Krężel Alain Wagner
author_sort	Sylvain Ursuegui
title	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_short	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_full	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_fullStr	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_full_unstemmed	An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
title_sort	in vivo strategy to counteract post-administration anticoagulant activity of azido-warfarin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ebda2b9fe32443d9b94c7789c9666492
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An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin

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