Clinical and pharmacological monitoring of drug safety in pediatrics

The 95 cases of adverse drug reactions in children were registered in the Centre of Drug Safety Monitoring of Irkutsk Region from 2009 to 2015. In 21.4 % of cases, the coexistent affections developed. Children were allergic three times more often than adults. In 14.7 % of cases severe allergic react...

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Autores principales:	N. V. Verlan, E. O. Kochkina, A. V. Kochkin, L. V. Okhremchuk, A. V. Popadyuk
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	children drug reaction drugs safety monitoring adverse drug reaction Science Q
Acceso en línea:	https://doaj.org/article/ebdb44e8a9534f3490f6a497b2fee786
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spelling	oai:doaj.org-article:ebdb44e8a9534f3490f6a497b2fee7862021-11-23T06:14:34ZClinical and pharmacological monitoring of drug safety in pediatrics2541-94202587-959610.12737/21590https://doaj.org/article/ebdb44e8a9534f3490f6a497b2fee7862016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/221https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The 95 cases of adverse drug reactions in children were registered in the Centre of Drug Safety Monitoring of Irkutsk Region from 2009 to 2015. In 21.4 % of cases, the coexistent affections developed. Children were allergic three times more often than adults. In 14.7 % of cases severe allergic reactions were registered. Most often allergies occurred after taking immunotropic (62.2 %), antimicrobial (16.2 %) and nonsteroidal anti-inflammatory drugs (10.8 %). 10.5 % of cases concerned inefficient drug use in children under 3 years; and 36.8 % of cases concerned children aged 3 to 18 years. The following risk factors of inefficient antibiotic therapy in children with urinary system infections were determined: the duration of the disease up to 5 years, isolation of two or more infectious agents and concomitant infections of upper and lower urinary tract. Adverse drug reaction occurred more often when more than three drugs were prescribed at the same time. Such cases were generally registered in patients with infectious diseases and epilepsy. Risk of adverse reaction increased with the off-label drug use. Introduction of monitoring methods and prediction algorithms allowing to reveal with high probability and to prevent adverse drug reactions in children improved efficiency and quality of pharmacotherapyN. V. VerlanE. O. KochkinaA. V. KochkinL. V. OkhremchukA. V. PopadyukScientific Сentre for Family Health and Human Reproduction Problemsarticlechildrendrug reactiondrugssafety monitoringadverse drug reactionScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(1), Pp 29-32 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	children drug reaction drugs safety monitoring adverse drug reaction Science Q
spellingShingle	children drug reaction drugs safety monitoring adverse drug reaction Science Q N. V. Verlan E. O. Kochkina A. V. Kochkin L. V. Okhremchuk A. V. Popadyuk Clinical and pharmacological monitoring of drug safety in pediatrics
description	The 95 cases of adverse drug reactions in children were registered in the Centre of Drug Safety Monitoring of Irkutsk Region from 2009 to 2015. In 21.4 % of cases, the coexistent affections developed. Children were allergic three times more often than adults. In 14.7 % of cases severe allergic reactions were registered. Most often allergies occurred after taking immunotropic (62.2 %), antimicrobial (16.2 %) and nonsteroidal anti-inflammatory drugs (10.8 %). 10.5 % of cases concerned inefficient drug use in children under 3 years; and 36.8 % of cases concerned children aged 3 to 18 years. The following risk factors of inefficient antibiotic therapy in children with urinary system infections were determined: the duration of the disease up to 5 years, isolation of two or more infectious agents and concomitant infections of upper and lower urinary tract. Adverse drug reaction occurred more often when more than three drugs were prescribed at the same time. Such cases were generally registered in patients with infectious diseases and epilepsy. Risk of adverse reaction increased with the off-label drug use. Introduction of monitoring methods and prediction algorithms allowing to reveal with high probability and to prevent adverse drug reactions in children improved efficiency and quality of pharmacotherapy
format	article
author	N. V. Verlan E. O. Kochkina A. V. Kochkin L. V. Okhremchuk A. V. Popadyuk
author_facet	N. V. Verlan E. O. Kochkina A. V. Kochkin L. V. Okhremchuk A. V. Popadyuk
author_sort	N. V. Verlan
title	Clinical and pharmacological monitoring of drug safety in pediatrics
title_short	Clinical and pharmacological monitoring of drug safety in pediatrics
title_full	Clinical and pharmacological monitoring of drug safety in pediatrics
title_fullStr	Clinical and pharmacological monitoring of drug safety in pediatrics
title_full_unstemmed	Clinical and pharmacological monitoring of drug safety in pediatrics
title_sort	clinical and pharmacological monitoring of drug safety in pediatrics
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/ebdb44e8a9534f3490f6a497b2fee786
work_keys_str_mv	AT nvverlan clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics AT eokochkina clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics AT avkochkin clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics AT lvokhremchuk clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics AT avpopadyuk clinicalandpharmacologicalmonitoringofdrugsafetyinpediatrics
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Clinical and pharmacological monitoring of drug safety in pediatrics

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