Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

Bryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cell surface expression holding potential for immunot...

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Autores principales:	Clayton Hardman, Stephen Ho, Akira Shimizu, Quang Luu-Nguyen, Jack L. Sloane, Mohamed S. A. Soliman, Matthew D. Marsden, Jerome A. Zack, Paul A. Wender
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ebe37911de374c93a36c1ee604f378a0
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spelling	oai:doaj.org-article:ebe37911de374c93a36c1ee604f378a02021-12-02T17:31:23ZSynthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy10.1038/s41467-020-15742-72041-1723https://doaj.org/article/ebe37911de374c93a36c1ee604f378a02020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15742-7https://doaj.org/toc/2041-1723Bryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cell surface expression holding potential for immunotherapy.Clayton HardmanStephen HoAkira ShimizuQuang Luu-NguyenJack L. SloaneMohamed S. A. SolimanMatthew D. MarsdenJerome A. ZackPaul A. WenderNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Clayton Hardman Stephen Ho Akira Shimizu Quang Luu-Nguyen Jack L. Sloane Mohamed S. A. Soliman Matthew D. Marsden Jerome A. Zack Paul A. Wender Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
description	Bryostatin 1 is a unique therapeutic lead, however its scarce natural sources have hampered its use in treatment of human disease. Here, the authors use a scalable synthesis of bryostatin 1 to make close-in analogs which potently induce increased cell surface expression holding potential for immunotherapy.
format	article
author	Clayton Hardman Stephen Ho Akira Shimizu Quang Luu-Nguyen Jack L. Sloane Mohamed S. A. Soliman Matthew D. Marsden Jerome A. Zack Paul A. Wender
author_facet	Clayton Hardman Stephen Ho Akira Shimizu Quang Luu-Nguyen Jack L. Sloane Mohamed S. A. Soliman Matthew D. Marsden Jerome A. Zack Paul A. Wender
author_sort	Clayton Hardman
title	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_short	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_full	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_fullStr	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_full_unstemmed	Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy
title_sort	synthesis and evaluation of designed pkc modulators for enhanced cancer immunotherapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ebe37911de374c93a36c1ee604f378a0
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Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

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