Current Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms

The global production of polyethylene terephthalate (PET) is estimated to reach 87.16 million metric tons by 2022. After a single use, a remarkable part of PET is accumulated in the natural environment as plastic waste. Due to high hydrophobicity and high molecular weight, PET is hardly biodegraded...

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Autores principales:	Aneta K. Urbanek, Katarzyna E. Kosiorowska, Aleksandra M. Mirończuk
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	plastic degradation genetic engineering microorganisms PET protein Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/ebe8c844fa044138b41ef7b80ecaa1af
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spelling	oai:doaj.org-article:ebe8c844fa044138b41ef7b80ecaa1af2021-12-01T18:59:55ZCurrent Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms2296-418510.3389/fbioe.2021.771133https://doaj.org/article/ebe8c844fa044138b41ef7b80ecaa1af2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.771133/fullhttps://doaj.org/toc/2296-4185The global production of polyethylene terephthalate (PET) is estimated to reach 87.16 million metric tons by 2022. After a single use, a remarkable part of PET is accumulated in the natural environment as plastic waste. Due to high hydrophobicity and high molecular weight, PET is hardly biodegraded by wild-type microorganisms. To solve the global problem of uncontrolled pollution by PET, the degradation of plastic by genetically modified microorganisms has become a promising alternative for the plastic circular economy. In recent years many studies have been conducted to improve the microbial capacity for PET degradation. In this review, we summarize the current knowledge about metabolic engineering of microorganisms and protein engineering for increased biodegradation of PET. The focus is on mutations introduced to the enzymes of the hydrolase class—PETase, MHETase and cutinase—which in the last few years have attracted growing interest for the PET degradation processes. The modifications described in this work summarize the results obtained so far on the hydrolysis of polyethylene terephthalate based on the released degradation products of this polymer.Aneta K. UrbanekKatarzyna E. KosiorowskaAleksandra M. MirończukFrontiers Media S.A.articleplastic degradationgenetic engineeringmicroorganismsPETproteinBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	plastic degradation genetic engineering microorganisms PET protein Biotechnology TP248.13-248.65
spellingShingle	plastic degradation genetic engineering microorganisms PET protein Biotechnology TP248.13-248.65 Aneta K. Urbanek Katarzyna E. Kosiorowska Aleksandra M. Mirończuk Current Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms
description	The global production of polyethylene terephthalate (PET) is estimated to reach 87.16 million metric tons by 2022. After a single use, a remarkable part of PET is accumulated in the natural environment as plastic waste. Due to high hydrophobicity and high molecular weight, PET is hardly biodegraded by wild-type microorganisms. To solve the global problem of uncontrolled pollution by PET, the degradation of plastic by genetically modified microorganisms has become a promising alternative for the plastic circular economy. In recent years many studies have been conducted to improve the microbial capacity for PET degradation. In this review, we summarize the current knowledge about metabolic engineering of microorganisms and protein engineering for increased biodegradation of PET. The focus is on mutations introduced to the enzymes of the hydrolase class—PETase, MHETase and cutinase—which in the last few years have attracted growing interest for the PET degradation processes. The modifications described in this work summarize the results obtained so far on the hydrolysis of polyethylene terephthalate based on the released degradation products of this polymer.
format	article
author	Aneta K. Urbanek Katarzyna E. Kosiorowska Aleksandra M. Mirończuk
author_facet	Aneta K. Urbanek Katarzyna E. Kosiorowska Aleksandra M. Mirończuk
author_sort	Aneta K. Urbanek
title	Current Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms
title_short	Current Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms
title_full	Current Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms
title_fullStr	Current Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms
title_full_unstemmed	Current Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms
title_sort	current knowledge on polyethylene terephthalate degradation by genetically modified microorganisms
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ebe8c844fa044138b41ef7b80ecaa1af
work_keys_str_mv	AT anetakurbanek currentknowledgeonpolyethyleneterephthalatedegradationbygeneticallymodifiedmicroorganisms AT katarzynaekosiorowska currentknowledgeonpolyethyleneterephthalatedegradationbygeneticallymodifiedmicroorganisms AT aleksandrammironczuk currentknowledgeonpolyethyleneterephthalatedegradationbygeneticallymodifiedmicroorganisms
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Current Knowledge on Polyethylene Terephthalate Degradation by Genetically Modified Microorganisms

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