MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse models.

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Autores principales:	Florence Sonneville, Manon Ruffin, Christelle Coraux, Nathalie Rousselet, Philippe Le Rouzic, Sabine Blouquit-Laye, Harriet Corvol, Olivier Tabary
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ebe9c1b9abb94fe688798f585d120b14
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spelling	oai:doaj.org-article:ebe9c1b9abb94fe688798f585d120b142021-12-02T14:41:11ZMicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology10.1038/s41467-017-00813-z2041-1723https://doaj.org/article/ebe9c1b9abb94fe688798f585d120b142017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00813-zhttps://doaj.org/toc/2041-1723Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse models.Florence SonnevilleManon RuffinChristelle CorauxNathalie RousseletPhilippe Le RouzicSabine Blouquit-LayeHarriet CorvolOlivier TabaryNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florence Sonneville Manon Ruffin Christelle Coraux Nathalie Rousselet Philippe Le Rouzic Sabine Blouquit-Laye Harriet Corvol Olivier Tabary MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
description	Downregulation of the anoctamin 1 calcium channel in airway epithelial cells contributes to pathology in cystic fibrosis. Here the authors show that microRNA-9 targets anoctamin 1 and that inhibiting this interaction improves mucus dynamics in mouse models.
format	article
author	Florence Sonneville Manon Ruffin Christelle Coraux Nathalie Rousselet Philippe Le Rouzic Sabine Blouquit-Laye Harriet Corvol Olivier Tabary
author_facet	Florence Sonneville Manon Ruffin Christelle Coraux Nathalie Rousselet Philippe Le Rouzic Sabine Blouquit-Laye Harriet Corvol Olivier Tabary
author_sort	Florence Sonneville
title	MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
title_short	MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
title_full	MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
title_fullStr	MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
title_full_unstemmed	MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
title_sort	microrna-9 downregulates the ano1 chloride channel and contributes to cystic fibrosis lung pathology
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ebe9c1b9abb94fe688798f585d120b14
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MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

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