Anti-HIV-1 nanotherapeutics: promises and challenges for the future

Supriya D Mahajan,1 Ravikumar Aalinkeel,1 Wing-Cheung Law,2 Jessica L Reynolds,1 Bindukumar B Nair,1 Donald E Sykes,1 Ken-Tye Yong,4 Indrajit Roy,3 Paras N Prasad,2 Stanley A Schwartz11Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 2Institute for Lasers Photonics and Biop...

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Autores principales:	Mahajan SD, Aalinkeel R, Law WC, Reynolds JL, Nair BB, Sykes DE, Yong KT, Roy I, Prasad PN, Schwartz SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ebf4e433140f40bfa34056255b2e2b68
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spelling	oai:doaj.org-article:ebf4e433140f40bfa34056255b2e2b682021-12-02T02:48:33ZAnti-HIV-1 nanotherapeutics: promises and challenges for the future1176-91141178-2013https://doaj.org/article/ebf4e433140f40bfa34056255b2e2b682012-10-01T00:00:00Zhttp://www.dovepress.com/anti-hiv-1-nanotherapeutics-promises-and-challenges-for-the-future-a11194https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Supriya D Mahajan,1 Ravikumar Aalinkeel,1 Wing-Cheung Law,2 Jessica L Reynolds,1 Bindukumar B Nair,1 Donald E Sykes,1 Ken-Tye Yong,4 Indrajit Roy,3 Paras N Prasad,2 Stanley A Schwartz11Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 2Institute for Lasers Photonics and Biophotonics, State University of New York at Buffalo, Buffalo Niagara Medical Campus, Buffalo, NY, USA; 3Department of Chemistry, University of Delhi, Delhi, India; 4School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, SingaporeAbstract: The advent of highly active antiretroviral therapy (HAART) has significantly improved the prognosis for human immunodeficiency virus (HIV)-infected patients, however the adverse side effects associated with prolonged HAART therapy use continue. Although systemic viral load can be undetectable, the virus remains sequestered in anatomically privileged sites within the body. Nanotechnology-based delivery systems are being developed to target the virus within different tissue compartments and are being evaluated for their safety and efficacy. The current review outlines the various nanomaterials that are becoming increasingly used in biomedical applications by virtue of their robustness, safety, multimodality, and multifunctionality. Nanotechnology can revolutionize the field of HIV medicine by not only improving diagnosis, but also by improving delivery of antiretrovirals to targeted regions in the body and by significantly enhancing the efficacy of the currently available antiretroviral medications.Keywords: nanotherapeutics, HAART, HIV, nano, nanomedicine, drug deliveryMahajan SDAalinkeel RLaw WCReynolds JLNair BBSykes DEYong KTRoy IPrasad PNSchwartz SADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5301-5314 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mahajan SD Aalinkeel R Law WC Reynolds JL Nair BB Sykes DE Yong KT Roy I Prasad PN Schwartz SA Anti-HIV-1 nanotherapeutics: promises and challenges for the future
description	Supriya D Mahajan,1 Ravikumar Aalinkeel,1 Wing-Cheung Law,2 Jessica L Reynolds,1 Bindukumar B Nair,1 Donald E Sykes,1 Ken-Tye Yong,4 Indrajit Roy,3 Paras N Prasad,2 Stanley A Schwartz11Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 2Institute for Lasers Photonics and Biophotonics, State University of New York at Buffalo, Buffalo Niagara Medical Campus, Buffalo, NY, USA; 3Department of Chemistry, University of Delhi, Delhi, India; 4School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, SingaporeAbstract: The advent of highly active antiretroviral therapy (HAART) has significantly improved the prognosis for human immunodeficiency virus (HIV)-infected patients, however the adverse side effects associated with prolonged HAART therapy use continue. Although systemic viral load can be undetectable, the virus remains sequestered in anatomically privileged sites within the body. Nanotechnology-based delivery systems are being developed to target the virus within different tissue compartments and are being evaluated for their safety and efficacy. The current review outlines the various nanomaterials that are becoming increasingly used in biomedical applications by virtue of their robustness, safety, multimodality, and multifunctionality. Nanotechnology can revolutionize the field of HIV medicine by not only improving diagnosis, but also by improving delivery of antiretrovirals to targeted regions in the body and by significantly enhancing the efficacy of the currently available antiretroviral medications.Keywords: nanotherapeutics, HAART, HIV, nano, nanomedicine, drug delivery
format	article
author	Mahajan SD Aalinkeel R Law WC Reynolds JL Nair BB Sykes DE Yong KT Roy I Prasad PN Schwartz SA
author_facet	Mahajan SD Aalinkeel R Law WC Reynolds JL Nair BB Sykes DE Yong KT Roy I Prasad PN Schwartz SA
author_sort	Mahajan SD
title	Anti-HIV-1 nanotherapeutics: promises and challenges for the future
title_short	Anti-HIV-1 nanotherapeutics: promises and challenges for the future
title_full	Anti-HIV-1 nanotherapeutics: promises and challenges for the future
title_fullStr	Anti-HIV-1 nanotherapeutics: promises and challenges for the future
title_full_unstemmed	Anti-HIV-1 nanotherapeutics: promises and challenges for the future
title_sort	anti-hiv-1 nanotherapeutics: promises and challenges for the future
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/ebf4e433140f40bfa34056255b2e2b68
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Anti-HIV-1 nanotherapeutics: promises and challenges for the future

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