Identifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension

Stefania Gioia,1 Oliviero Riggio,1 Silvia Nardelli,1 Giulia d’Amati,2 Lorenzo Ridola1 1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; 2Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, ItalyCorrespond...

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Autores principales:	Gioia S, Riggio O, Nardelli S, d'Amati G, Ridola L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	porto-sinusoidal vascular liver disease idiopathic non-cirrhotic portal hypertension portal vein thrombosis portal hypertension Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/ebf5b77bbbf54ade85802fd1fa6bb82d
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spelling	oai:doaj.org-article:ebf5b77bbbf54ade85802fd1fa6bb82d2021-12-02T19:36:57ZIdentifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension1179-1535https://doaj.org/article/ebf5b77bbbf54ade85802fd1fa6bb82d2021-11-01T00:00:00Zhttps://www.dovepress.com/identifying-patients-at-high-risk-of-developing-non-cirrhotic-portal-h-peer-reviewed-fulltext-article-HMERhttps://doaj.org/toc/1179-1535Stefania Gioia,1 Oliviero Riggio,1 Silvia Nardelli,1 Giulia d’Amati,2 Lorenzo Ridola1 1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; 2Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, ItalyCorrespondence: Stefania GioiaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyTel +39 06 49970463Email stensgioia@hotmail.comAbstract: The term porto-sinusoidal vascular disease (PSVD) has been recently proposed to replace the term idiopathic non-cirrhotic portal hypertension (INCPH) to describe patients with or without signs of portal hypertension and typical histological lesions involving the portal venules or sinusoids in the absence of cirrhosis. According to the new definition, the presence of known causes of liver disease as well as of portal vein thrombosis does not rule out PSVD. Therefore, the patients in whom the diagnosis of PSVD is possible are much more than the patients strictly fulfilling the diagnostic criteria for INCPH. In this setting, the clinical challenge for the hepatologist is to identify patients at risk of developing PSVD and to indicate liver biopsy to confirm the diagnosis. We describe some possible scenarios in which PSVD should always be suspected, and we provide some tools useful to reach the diagnosis of PSVD.Keywords: porto-sinusoidal vascular liver disease, idiopathic non-cirrhotic portal hypertension, portal vein thrombosis, portal hypertensionGioia SRiggio ONardelli Sd'Amati GRidola LDove Medical Pressarticleporto-sinusoidal vascular liver diseaseidiopathic non-cirrhotic portal hypertensionportal vein thrombosisportal hypertensionDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 13, Pp 105-111 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	porto-sinusoidal vascular liver disease idiopathic non-cirrhotic portal hypertension portal vein thrombosis portal hypertension Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	porto-sinusoidal vascular liver disease idiopathic non-cirrhotic portal hypertension portal vein thrombosis portal hypertension Diseases of the digestive system. Gastroenterology RC799-869 Gioia S Riggio O Nardelli S d'Amati G Ridola L Identifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension
description	Stefania Gioia,1 Oliviero Riggio,1 Silvia Nardelli,1 Giulia d’Amati,2 Lorenzo Ridola1 1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy; 2Department of Radiological, Oncological, and Pathological Sciences, Sapienza University of Rome, Rome, ItalyCorrespondence: Stefania GioiaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyTel +39 06 49970463Email stensgioia@hotmail.comAbstract: The term porto-sinusoidal vascular disease (PSVD) has been recently proposed to replace the term idiopathic non-cirrhotic portal hypertension (INCPH) to describe patients with or without signs of portal hypertension and typical histological lesions involving the portal venules or sinusoids in the absence of cirrhosis. According to the new definition, the presence of known causes of liver disease as well as of portal vein thrombosis does not rule out PSVD. Therefore, the patients in whom the diagnosis of PSVD is possible are much more than the patients strictly fulfilling the diagnostic criteria for INCPH. In this setting, the clinical challenge for the hepatologist is to identify patients at risk of developing PSVD and to indicate liver biopsy to confirm the diagnosis. We describe some possible scenarios in which PSVD should always be suspected, and we provide some tools useful to reach the diagnosis of PSVD.Keywords: porto-sinusoidal vascular liver disease, idiopathic non-cirrhotic portal hypertension, portal vein thrombosis, portal hypertension
format	article
author	Gioia S Riggio O Nardelli S d'Amati G Ridola L
author_facet	Gioia S Riggio O Nardelli S d'Amati G Ridola L
author_sort	Gioia S
title	Identifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension
title_short	Identifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension
title_full	Identifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension
title_fullStr	Identifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension
title_full_unstemmed	Identifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension
title_sort	identifying patients at high risk of developing non-cirrhotic portal hypertension
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ebf5b77bbbf54ade85802fd1fa6bb82d
work_keys_str_mv	AT gioias identifyingpatientsathighriskofdevelopingnoncirrhoticportalhypertension AT riggioo identifyingpatientsathighriskofdevelopingnoncirrhoticportalhypertension AT nardellis identifyingpatientsathighriskofdevelopingnoncirrhoticportalhypertension AT damatig identifyingpatientsathighriskofdevelopingnoncirrhoticportalhypertension AT ridolal identifyingpatientsathighriskofdevelopingnoncirrhoticportalhypertension
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Identifying Patients at High Risk of Developing Non-Cirrhotic Portal Hypertension

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