Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.

<h4>Background</h4>Invariant Natural Killer T (iNKT) cells represent a determinant in the course of infections and diseases, however, their role in the pathogenesis of non-infectious co-morbidities in HIV-positive patients is unknown.<h4>Methods</h4>Flow cytometry was used to...

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Autores principales:	Camilla Tincati, Matteo Basilissi, Elisabetta Sinigaglia, Esther Merlini, Giovanni Carpani, Antonella d'Arminio Monforte, Giulia Marchetti
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ebf86645bb9b4745b57016c48926c21f
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spelling	oai:doaj.org-article:ebf86645bb9b4745b57016c48926c21f2021-11-25T05:56:11ZInvariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.1932-620310.1371/journal.pone.0110287https://doaj.org/article/ebf86645bb9b4745b57016c48926c21f2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110287https://doaj.org/toc/1932-6203<h4>Background</h4>Invariant Natural Killer T (iNKT) cells represent a determinant in the course of infections and diseases, however, their role in the pathogenesis of non-infectious co-morbidities in HIV-positive patients is unknown.<h4>Methods</h4>Flow cytometry was used to investigate iNKT cell frequency, phenotype and function in HIV-infected patients on HAART with bone and/or cardiovascular disorders and in HIV-positive controls free from co-morbidities.<h4>Results</h4>iNKT cells from subjects with bone and cardiovascular impairment expressed high levels of CD161 and predominantly secreted TNF. iNKT cells from individuals with bone disease alone did not show any distinctive phenotypical or functional characteristics. The functional capacity of iNKT cells in patients with cardiovascular disorder was impaired with no cytokine release upon stimulation.<h4>Conclusion</h4>iNKT cells may have a role in non-infectious co-morbidities in treated HIV disease, possibly through the exacerbation of inflammation. Further studies are needed to investigate iNKT cells in the pathogenesis of non-communicable disorders in HIV infection.Camilla TincatiMatteo BasilissiElisabetta SinigagliaEsther MerliniGiovanni CarpaniAntonella d'Arminio MonforteGiulia MarchettiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110287 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Camilla Tincati Matteo Basilissi Elisabetta Sinigaglia Esther Merlini Giovanni Carpani Antonella d'Arminio Monforte Giulia Marchetti Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.
description	<h4>Background</h4>Invariant Natural Killer T (iNKT) cells represent a determinant in the course of infections and diseases, however, their role in the pathogenesis of non-infectious co-morbidities in HIV-positive patients is unknown.<h4>Methods</h4>Flow cytometry was used to investigate iNKT cell frequency, phenotype and function in HIV-infected patients on HAART with bone and/or cardiovascular disorders and in HIV-positive controls free from co-morbidities.<h4>Results</h4>iNKT cells from subjects with bone and cardiovascular impairment expressed high levels of CD161 and predominantly secreted TNF. iNKT cells from individuals with bone disease alone did not show any distinctive phenotypical or functional characteristics. The functional capacity of iNKT cells in patients with cardiovascular disorder was impaired with no cytokine release upon stimulation.<h4>Conclusion</h4>iNKT cells may have a role in non-infectious co-morbidities in treated HIV disease, possibly through the exacerbation of inflammation. Further studies are needed to investigate iNKT cells in the pathogenesis of non-communicable disorders in HIV infection.
format	article
author	Camilla Tincati Matteo Basilissi Elisabetta Sinigaglia Esther Merlini Giovanni Carpani Antonella d'Arminio Monforte Giulia Marchetti
author_facet	Camilla Tincati Matteo Basilissi Elisabetta Sinigaglia Esther Merlini Giovanni Carpani Antonella d'Arminio Monforte Giulia Marchetti
author_sort	Camilla Tincati
title	Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.
title_short	Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.
title_full	Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.
title_fullStr	Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.
title_full_unstemmed	Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.
title_sort	invariant natural killer t (inkt) cells in haart-treated, hiv-positive patients with bone and cardiovascular impairment.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/ebf86645bb9b4745b57016c48926c21f
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Invariant natural killer T (iNKT) cells in HAART-treated, HIV-positive patients with bone and cardiovascular impairment.

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