A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19

Abstract The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVac, a replication-competent vesicular stomatitis virus (VSV) vaccine vector that ex...

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Autores principales:	Delphine C. Malherbe, Drishya Kurup, Christoph Wirblich, Adam J. Ronk, Chad Mire, Natalia Kuzmina, Noor Shaik, Sivakumar Periasamy, Matthew A. Hyde, Julie M. Williams, Pei-Yong Shi, Matthias J. Schnell, Alexander Bukreyev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ebf985f490e445e383c6a2b50cb40eb9
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spelling	oai:doaj.org-article:ebf985f490e445e383c6a2b50cb40eb92021-12-02T16:26:27ZA single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-1910.1038/s41541-021-00352-12059-0105https://doaj.org/article/ebf985f490e445e383c6a2b50cb40eb92021-07-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00352-1https://doaj.org/toc/2059-0105Abstract The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVac, a replication-competent vesicular stomatitis virus (VSV) vaccine vector that expresses the S1 subunit of SARS-CoV-2 spike protein. We used golden Syrian hamsters as animal models of severe COVID-19 to test the efficacy of the ConVac vaccine. A single vaccine dose elicited high levels of SARS-CoV-2 specific binding and neutralizing antibodies; following intranasal challenge with SARS-CoV-2, animals were protected from weight loss and viral replication in the lungs. No enhanced pathology was observed in vaccinated animals upon challenge, but some inflammation was still detected. The data indicate rapid control of SARS-CoV-2 replication by the S1-based VSV-vectored SARS-CoV-2 ConVac vaccine.Delphine C. MalherbeDrishya KurupChristoph WirblichAdam J. RonkChad MireNatalia KuzminaNoor ShaikSivakumar PeriasamyMatthew A. HydeJulie M. WilliamsPei-Yong ShiMatthias J. SchnellAlexander BukreyevNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Delphine C. Malherbe Drishya Kurup Christoph Wirblich Adam J. Ronk Chad Mire Natalia Kuzmina Noor Shaik Sivakumar Periasamy Matthew A. Hyde Julie M. Williams Pei-Yong Shi Matthias J. Schnell Alexander Bukreyev A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
description	Abstract The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVac, a replication-competent vesicular stomatitis virus (VSV) vaccine vector that expresses the S1 subunit of SARS-CoV-2 spike protein. We used golden Syrian hamsters as animal models of severe COVID-19 to test the efficacy of the ConVac vaccine. A single vaccine dose elicited high levels of SARS-CoV-2 specific binding and neutralizing antibodies; following intranasal challenge with SARS-CoV-2, animals were protected from weight loss and viral replication in the lungs. No enhanced pathology was observed in vaccinated animals upon challenge, but some inflammation was still detected. The data indicate rapid control of SARS-CoV-2 replication by the S1-based VSV-vectored SARS-CoV-2 ConVac vaccine.
format	article
author	Delphine C. Malherbe Drishya Kurup Christoph Wirblich Adam J. Ronk Chad Mire Natalia Kuzmina Noor Shaik Sivakumar Periasamy Matthew A. Hyde Julie M. Williams Pei-Yong Shi Matthias J. Schnell Alexander Bukreyev
author_facet	Delphine C. Malherbe Drishya Kurup Christoph Wirblich Adam J. Ronk Chad Mire Natalia Kuzmina Noor Shaik Sivakumar Periasamy Matthew A. Hyde Julie M. Williams Pei-Yong Shi Matthias J. Schnell Alexander Bukreyev
author_sort	Delphine C. Malherbe
title	A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
title_short	A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
title_full	A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
title_fullStr	A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
title_full_unstemmed	A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
title_sort	single dose of replication-competent vsv-vectored vaccine expressing sars-cov-2 s1 protects against virus replication in a hamster model of severe covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ebf985f490e445e383c6a2b50cb40eb9
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A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19

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