Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy

Aim. To determine the level of inflammation markers and their relation to endothelial dysfunction and insulin resistance in patents with type 2 diabetesmellitus and cardiovascular form of diabetic autonomous neuropathy. Materials and methods. A total of 87 patients aged 45-66 years were examined f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Irina Arkad'evna Bondar', Olesya Yur'evna Shabel'nikova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	diabetes mellitus autonomous neuropathy inflammation markers insulin resistance endothelial dysfunction Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/ebfb0c91ad714245a71607b14386b380
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ebfb0c91ad714245a71607b14386b380
record_format	dspace
spelling	oai:doaj.org-article:ebfb0c91ad714245a71607b14386b3802021-11-14T09:00:14ZMarkers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy2072-03512072-037810.14341/2072-0351-5705https://doaj.org/article/ebfb0c91ad714245a71607b14386b3802009-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5705https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To determine the level of inflammation markers and their relation to endothelial dysfunction and insulin resistance in patents with type 2 diabetesmellitus and cardiovascular form of diabetic autonomous neuropathy. Materials and methods. A total of 87 patients aged 45-66 years were examined for blood insulin level, insulin resistance index (HOMA-IR), CRP,and anti-inflammatory cytokine (TNF-a, IL-1-beta, IL-6) levels. Endothelial dysfunction was estimated based on quantitative Willebrand factorassay. Vegetative disorders were detected from reflex cardiovascular ECG data. Results. The development of cardiovascular form of diabetic autonomous neuropathy in patents with type 2 diabetes depended on diabetes duration,quality of carbohydrate metabolism compensation, levels of hyperinsulinemia and insulin resistance. Mean levels of Willebrand factors andinflammation markers in patents with type 2 diabetes and overt vegetative dysfunction were significantly higher than in diabetic patients withoutautonomous neuropathy. Correlation analysis revealed significant correlation of CRP and IL-6 levels with results of standard ECG tests. Conclusion. Results of the study demonstrate chronic inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomousneuropathy. Increased level of inflammation markers and its relation to severity of vegetative disorders and endothelial dysfunction confirm the roleof inflammation in pathogenesis of nervous co-morbidity in patents with type 2 diabetes.Irina Arkad'evna Bondar'Olesya Yur'evna Shabel'nikovaEndocrinology Research Centrearticlediabetes mellitusautonomous neuropathyinflammation markersinsulin resistanceendothelial dysfunctionNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 4, Pp 51-55 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus autonomous neuropathy inflammation markers insulin resistance endothelial dysfunction Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus autonomous neuropathy inflammation markers insulin resistance endothelial dysfunction Nutritional diseases. Deficiency diseases RC620-627 Irina Arkad'evna Bondar' Olesya Yur'evna Shabel'nikova Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy
description	Aim. To determine the level of inflammation markers and their relation to endothelial dysfunction and insulin resistance in patents with type 2 diabetesmellitus and cardiovascular form of diabetic autonomous neuropathy. Materials and methods. A total of 87 patients aged 45-66 years were examined for blood insulin level, insulin resistance index (HOMA-IR), CRP,and anti-inflammatory cytokine (TNF-a, IL-1-beta, IL-6) levels. Endothelial dysfunction was estimated based on quantitative Willebrand factorassay. Vegetative disorders were detected from reflex cardiovascular ECG data. Results. The development of cardiovascular form of diabetic autonomous neuropathy in patents with type 2 diabetes depended on diabetes duration,quality of carbohydrate metabolism compensation, levels of hyperinsulinemia and insulin resistance. Mean levels of Willebrand factors andinflammation markers in patents with type 2 diabetes and overt vegetative dysfunction were significantly higher than in diabetic patients withoutautonomous neuropathy. Correlation analysis revealed significant correlation of CRP and IL-6 levels with results of standard ECG tests. Conclusion. Results of the study demonstrate chronic inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomousneuropathy. Increased level of inflammation markers and its relation to severity of vegetative disorders and endothelial dysfunction confirm the roleof inflammation in pathogenesis of nervous co-morbidity in patents with type 2 diabetes.
format	article
author	Irina Arkad'evna Bondar' Olesya Yur'evna Shabel'nikova
author_facet	Irina Arkad'evna Bondar' Olesya Yur'evna Shabel'nikova
author_sort	Irina Arkad'evna Bondar'
title	Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy
title_short	Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy
title_full	Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy
title_fullStr	Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy
title_full_unstemmed	Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy
title_sort	markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/ebfb0c91ad714245a71607b14386b380
work_keys_str_mv	AT irinaarkadevnabondar markersofinflammationinpatentswithtype2diabetesandcardiovascularformofdiabeticautonomousneuropathy AT olesyayurevnashabelnikova markersofinflammationinpatentswithtype2diabetesandcardiovascularformofdiabeticautonomousneuropathy
_version_	1718429687699472384

Markers of inflammation in patents with type 2 diabetes and cardiovascular form of diabetic autonomous neuropathy

Ejemplares similares