3D printing fluorescent material with tunable optical properties

Abstract The 3D printing of fluorescent materials could help develop, validate, and translate imaging technologies, including systems for fluorescence-guided surgery. Despite advances in 3D printing techniques for optical targets, no comprehensive method has been demonstrated for the simultaneous in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alberto J. Ruiz, Sadhya Garg, Samuel S. Streeter, Mia K. Giallorenzi, Ethan P. M. LaRochelle, Kimberley S. Samkoe, Brian W. Pogue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ebfdec7282a3444cbe1e7162605a405c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ebfdec7282a3444cbe1e7162605a405c
record_format	dspace
spelling	oai:doaj.org-article:ebfdec7282a3444cbe1e7162605a405c2021-12-02T18:53:19Z3D printing fluorescent material with tunable optical properties10.1038/s41598-021-96496-02045-2322https://doaj.org/article/ebfdec7282a3444cbe1e7162605a405c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96496-0https://doaj.org/toc/2045-2322Abstract The 3D printing of fluorescent materials could help develop, validate, and translate imaging technologies, including systems for fluorescence-guided surgery. Despite advances in 3D printing techniques for optical targets, no comprehensive method has been demonstrated for the simultaneous incorporation of fluorophores and fine-tuning of absorption and scattering properties. Here, we introduce a photopolymer-based 3D printing method for manufacturing fluorescent material with tunable optical properties. The results demonstrate the ability to 3D print various individual fluorophores at reasonably high fluorescence yields, including IR-125, quantum dots, methylene blue, and rhodamine 590. Furthermore, tuning of the absorption and reduced scattering coefficients is demonstrated within the relevant mamalian soft tissue coefficient ranges of 0.005–0.05 mm−1 and 0.2–1.5 mm−1, respectively. Fabrication of fluorophore-doped biomimicking and complex geometric structures validated the ability to print feature sizes less than 200 μm. The presented methods and optical characterization techniques provide the foundation for the manufacturing of solid 3D printed fluorescent structures, with direct relevance to biomedical optics and the broad adoption of fast manufacturing methods in fluorescence imaging.Alberto J. RuizSadhya GargSamuel S. StreeterMia K. GiallorenziEthan P. M. LaRochelleKimberley S. SamkoeBrian W. PogueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alberto J. Ruiz Sadhya Garg Samuel S. Streeter Mia K. Giallorenzi Ethan P. M. LaRochelle Kimberley S. Samkoe Brian W. Pogue 3D printing fluorescent material with tunable optical properties
description	Abstract The 3D printing of fluorescent materials could help develop, validate, and translate imaging technologies, including systems for fluorescence-guided surgery. Despite advances in 3D printing techniques for optical targets, no comprehensive method has been demonstrated for the simultaneous incorporation of fluorophores and fine-tuning of absorption and scattering properties. Here, we introduce a photopolymer-based 3D printing method for manufacturing fluorescent material with tunable optical properties. The results demonstrate the ability to 3D print various individual fluorophores at reasonably high fluorescence yields, including IR-125, quantum dots, methylene blue, and rhodamine 590. Furthermore, tuning of the absorption and reduced scattering coefficients is demonstrated within the relevant mamalian soft tissue coefficient ranges of 0.005–0.05 mm−1 and 0.2–1.5 mm−1, respectively. Fabrication of fluorophore-doped biomimicking and complex geometric structures validated the ability to print feature sizes less than 200 μm. The presented methods and optical characterization techniques provide the foundation for the manufacturing of solid 3D printed fluorescent structures, with direct relevance to biomedical optics and the broad adoption of fast manufacturing methods in fluorescence imaging.
format	article
author	Alberto J. Ruiz Sadhya Garg Samuel S. Streeter Mia K. Giallorenzi Ethan P. M. LaRochelle Kimberley S. Samkoe Brian W. Pogue
author_facet	Alberto J. Ruiz Sadhya Garg Samuel S. Streeter Mia K. Giallorenzi Ethan P. M. LaRochelle Kimberley S. Samkoe Brian W. Pogue
author_sort	Alberto J. Ruiz
title	3D printing fluorescent material with tunable optical properties
title_short	3D printing fluorescent material with tunable optical properties
title_full	3D printing fluorescent material with tunable optical properties
title_fullStr	3D printing fluorescent material with tunable optical properties
title_full_unstemmed	3D printing fluorescent material with tunable optical properties
title_sort	3d printing fluorescent material with tunable optical properties
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ebfdec7282a3444cbe1e7162605a405c
work_keys_str_mv	AT albertojruiz 3dprintingfluorescentmaterialwithtunableopticalproperties AT sadhyagarg 3dprintingfluorescentmaterialwithtunableopticalproperties AT samuelsstreeter 3dprintingfluorescentmaterialwithtunableopticalproperties AT miakgiallorenzi 3dprintingfluorescentmaterialwithtunableopticalproperties AT ethanpmlarochelle 3dprintingfluorescentmaterialwithtunableopticalproperties AT kimberleyssamkoe 3dprintingfluorescentmaterialwithtunableopticalproperties AT brianwpogue 3dprintingfluorescentmaterialwithtunableopticalproperties
_version_	1718377361426087936

3D printing fluorescent material with tunable optical properties

Ejemplares similares