Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses

Abstract Surface inactivation of human microbial pathogens has a long history. The Smith Papyrus (2600 ~ 2200 B.C.) described the use of copper surfaces to sterilize chest wounds and drinking water. Brass and bronze on doorknobs can discourage microbial spread in hospitals, and metal-base surface co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giuseppe Pezzotti, Francesco Boschetto, Eriko Ohgitani, Yuki Fujita, Wenliang Zhu, Elia Marin, Bryan J. McEntire, B. Sonny Bal, Osam Mazda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec001d1b5c2940999eea08f11fa46a9f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ec001d1b5c2940999eea08f11fa46a9f
record_format	dspace
spelling	oai:doaj.org-article:ec001d1b5c2940999eea08f11fa46a9f2021-12-02T14:06:56ZSilicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses10.1038/s41598-021-82608-32045-2322https://doaj.org/article/ec001d1b5c2940999eea08f11fa46a9f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82608-3https://doaj.org/toc/2045-2322Abstract Surface inactivation of human microbial pathogens has a long history. The Smith Papyrus (2600 ~ 2200 B.C.) described the use of copper surfaces to sterilize chest wounds and drinking water. Brass and bronze on doorknobs can discourage microbial spread in hospitals, and metal-base surface coatings are used in hygiene-sensitive environments, both as inactivators and modulators of cellular immunity. A limitation of these approaches is that the reactive oxygen radicals (ROS) generated at metal surfaces also damage human cells by oxidizing their proteins and lipids. Silicon nitride (Si3N4) is a non-oxide ceramic compound with known surface bacterial resistance. We show here that off-stoichiometric reactions at Si3N4 surfaces are also capable of inactivating different types of single-stranded RNA (ssRNA) viruses independent of whether their structure presents an envelop or not. The antiviral property of Si3N4 derives from a hydrolysis reaction at its surface and the subsequent formation of reactive nitrogen species (RNS) in doses that could be metabolized by mammalian cells but are lethal to pathogens. Real-time reverse transcription (RT)-polymerase chain reaction (PCR) tests of viral RNA and in situ Raman spectroscopy suggested that the products of Si3N4 hydrolysis directly react with viral proteins and RNA. Si3N4 may have a role in controlling human epidemics related to ssRNA mutant viruses.Giuseppe PezzottiFrancesco BoschettoEriko OhgitaniYuki FujitaWenliang ZhuElia MarinBryan J. McEntireB. Sonny BalOsam MazdaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giuseppe Pezzotti Francesco Boschetto Eriko Ohgitani Yuki Fujita Wenliang Zhu Elia Marin Bryan J. McEntire B. Sonny Bal Osam Mazda Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses
description	Abstract Surface inactivation of human microbial pathogens has a long history. The Smith Papyrus (2600 ~ 2200 B.C.) described the use of copper surfaces to sterilize chest wounds and drinking water. Brass and bronze on doorknobs can discourage microbial spread in hospitals, and metal-base surface coatings are used in hygiene-sensitive environments, both as inactivators and modulators of cellular immunity. A limitation of these approaches is that the reactive oxygen radicals (ROS) generated at metal surfaces also damage human cells by oxidizing their proteins and lipids. Silicon nitride (Si3N4) is a non-oxide ceramic compound with known surface bacterial resistance. We show here that off-stoichiometric reactions at Si3N4 surfaces are also capable of inactivating different types of single-stranded RNA (ssRNA) viruses independent of whether their structure presents an envelop or not. The antiviral property of Si3N4 derives from a hydrolysis reaction at its surface and the subsequent formation of reactive nitrogen species (RNS) in doses that could be metabolized by mammalian cells but are lethal to pathogens. Real-time reverse transcription (RT)-polymerase chain reaction (PCR) tests of viral RNA and in situ Raman spectroscopy suggested that the products of Si3N4 hydrolysis directly react with viral proteins and RNA. Si3N4 may have a role in controlling human epidemics related to ssRNA mutant viruses.
format	article
author	Giuseppe Pezzotti Francesco Boschetto Eriko Ohgitani Yuki Fujita Wenliang Zhu Elia Marin Bryan J. McEntire B. Sonny Bal Osam Mazda
author_facet	Giuseppe Pezzotti Francesco Boschetto Eriko Ohgitani Yuki Fujita Wenliang Zhu Elia Marin Bryan J. McEntire B. Sonny Bal Osam Mazda
author_sort	Giuseppe Pezzotti
title	Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses
title_short	Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses
title_full	Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses
title_fullStr	Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses
title_full_unstemmed	Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses
title_sort	silicon nitride: a potent solid-state bioceramic inactivator of ssrna viruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec001d1b5c2940999eea08f11fa46a9f
work_keys_str_mv	AT giuseppepezzotti siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses AT francescoboschetto siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses AT erikoohgitani siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses AT yukifujita siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses AT wenliangzhu siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses AT eliamarin siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses AT bryanjmcentire siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses AT bsonnybal siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses AT osammazda siliconnitrideapotentsolidstatebioceramicinactivatorofssrnaviruses
_version_	1718391997620813824

Silicon nitride: a potent solid-state bioceramic inactivator of ssRNA viruses

Ejemplares similares