Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model

Mohammed Al-Hariri,1 Ahmed Alsunni,1 Mohammad Habeeb Shaikh,1 Tharwat Gamal Eldin,1 Kholoud Al Ghamdi,1 Abdulelah Fawzi Alharbi,2 Hussain Alhawaj,3 Shahanas Chathoth4 1Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2Department of Internal...

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Autores principales:	Al-Hariri M, Alsunni A, Shaikh MH, Gamal Eldin T, Al Ghamdi K, Alharbi AF, Alhawaj H, Chathoth S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cape swimming rats interleukins proinflammatory Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ec015294981a41c38ec065ea2fa08e58
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spelling	oai:doaj.org-article:ec015294981a41c38ec065ea2fa08e582021-12-02T19:31:40ZCaffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model1178-7031https://doaj.org/article/ec015294981a41c38ec065ea2fa08e582021-11-01T00:00:00Zhttps://www.dovepress.com/caffeic-acid-phenethyl-ester-reduces-pro-inflammatory-cytokines-in-mod-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Mohammed Al-Hariri,1 Ahmed Alsunni,1 Mohammad Habeeb Shaikh,1 Tharwat Gamal Eldin,1 Kholoud Al Ghamdi,1 Abdulelah Fawzi Alharbi,2 Hussain Alhawaj,3 Shahanas Chathoth4 1Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 3Department of Environmental Health, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabi; 4Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Mohammed Al-HaririDepartment of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O. Box 2114-31451, Dammam, Saudi ArabiaTel +966 50-727-5028Email mtalhariri@iau.edu.saBackground: Caffeic acid phenethyl ester (CAPE) is a naturally occurring polyphenolic concentrated in propolis of honeybee hives. CAPE has been shown various physiological and pharmacologic properties. The aim of the present study was to investigate the effects of CAPE on proinflammatory markers in growing rats by performing the moderate swimming test.Methods: A total number of 21 male Wistar albino rats were separated into three groups (n = 7): sedentary: negative control group; exercise: positive control group received vehicle orally and exercise + CAPE: CAPE treated group: treated with CAPE (20 mg/kg) orally 30 min before exercise, for 5 days. The animals were left free to swim in the tank, 20 minutes/day for 5 days. At 24 hours after finishing the experiment, rats were euthanised and blood was collected to analyze the level of serum interleukin IL-6 and tumor necrosis factor–α (TNF-α).Results: Growing rats subjected to the moderate swimming test and in those treated with CAPE showed a lower level of TNF-α compared to the negative control. More interestingly, the one-way ANOVA data demonstrated a decreased level of proinflammatory IL-6 in the CAPE-treated group compared to the negative control.Conclusion: Results of this study indicate that short-term administration of CAPE may modulate proinflammatory cytokine profiles during moderate exercise and may serve to boost the anti-inflammatory effects of exercise. Further studies are needed to evaluate the efficacy and safety of long-term administration of CAPE as an adjective anti-inflammatory agent.Keywords: CAPE, swimming, rats, interleukins, proinflammatoryAl-Hariri MAlsunni AShaikh MHGamal Eldin TAl Ghamdi KAlharbi AFAlhawaj HChathoth SDove Medical PressarticlecapeswimmingratsinterleukinsproinflammatoryPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 5653-5657 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cape swimming rats interleukins proinflammatory Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	cape swimming rats interleukins proinflammatory Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Al-Hariri M Alsunni A Shaikh MH Gamal Eldin T Al Ghamdi K Alharbi AF Alhawaj H Chathoth S Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model
description	Mohammed Al-Hariri,1 Ahmed Alsunni,1 Mohammad Habeeb Shaikh,1 Tharwat Gamal Eldin,1 Kholoud Al Ghamdi,1 Abdulelah Fawzi Alharbi,2 Hussain Alhawaj,3 Shahanas Chathoth4 1Department of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 3Department of Environmental Health, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabi; 4Department of Biochemistry, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaCorrespondence: Mohammed Al-HaririDepartment of Physiology, College of Medicine, Imam Abdulrahman Bin Faisal University, P.O. Box 2114-31451, Dammam, Saudi ArabiaTel +966 50-727-5028Email mtalhariri@iau.edu.saBackground: Caffeic acid phenethyl ester (CAPE) is a naturally occurring polyphenolic concentrated in propolis of honeybee hives. CAPE has been shown various physiological and pharmacologic properties. The aim of the present study was to investigate the effects of CAPE on proinflammatory markers in growing rats by performing the moderate swimming test.Methods: A total number of 21 male Wistar albino rats were separated into three groups (n = 7): sedentary: negative control group; exercise: positive control group received vehicle orally and exercise + CAPE: CAPE treated group: treated with CAPE (20 mg/kg) orally 30 min before exercise, for 5 days. The animals were left free to swim in the tank, 20 minutes/day for 5 days. At 24 hours after finishing the experiment, rats were euthanised and blood was collected to analyze the level of serum interleukin IL-6 and tumor necrosis factor–α (TNF-α).Results: Growing rats subjected to the moderate swimming test and in those treated with CAPE showed a lower level of TNF-α compared to the negative control. More interestingly, the one-way ANOVA data demonstrated a decreased level of proinflammatory IL-6 in the CAPE-treated group compared to the negative control.Conclusion: Results of this study indicate that short-term administration of CAPE may modulate proinflammatory cytokine profiles during moderate exercise and may serve to boost the anti-inflammatory effects of exercise. Further studies are needed to evaluate the efficacy and safety of long-term administration of CAPE as an adjective anti-inflammatory agent.Keywords: CAPE, swimming, rats, interleukins, proinflammatory
format	article
author	Al-Hariri M Alsunni A Shaikh MH Gamal Eldin T Al Ghamdi K Alharbi AF Alhawaj H Chathoth S
author_facet	Al-Hariri M Alsunni A Shaikh MH Gamal Eldin T Al Ghamdi K Alharbi AF Alhawaj H Chathoth S
author_sort	Al-Hariri M
title	Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model
title_short	Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model
title_full	Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model
title_fullStr	Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model
title_full_unstemmed	Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model
title_sort	caffeic acid phenethyl ester reduces pro inflammatory cytokines in moderate swimming test in growing rats model
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ec015294981a41c38ec065ea2fa08e58
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Caffeic Acid Phenethyl Ester reduces Pro Inflammatory Cytokines in Moderate Swimming Test in Growing Rats Model

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