MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

SMAD7 is a transcriptional target and a negative regulator of TGFβ signalling forming a negative feedback loop. Here the authors show that in cancer cells TGFβ activates the expression of microRNA-182 that suppresses SMAD7 protein, promoting TGFβ-mediated breast tumour invasion and bone metastasis....

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Autores principales:	Jingyi Yu, Rong Lei, Xueqian Zhuang, Xiaoxun Li, Gang Li, Sima Lev, Miguel F. Segura, Xue Zhang, Guohong Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec0353b3c0b54b89a9b62aad167220c3
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spelling	oai:doaj.org-article:ec0353b3c0b54b89a9b62aad167220c32021-12-02T16:49:42ZMicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells10.1038/ncomms138842041-1723https://doaj.org/article/ec0353b3c0b54b89a9b62aad167220c32016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13884https://doaj.org/toc/2041-1723SMAD7 is a transcriptional target and a negative regulator of TGFβ signalling forming a negative feedback loop. Here the authors show that in cancer cells TGFβ activates the expression of microRNA-182 that suppresses SMAD7 protein, promoting TGFβ-mediated breast tumour invasion and bone metastasis.Jingyi YuRong LeiXueqian ZhuangXiaoxun LiGang LiSima LevMiguel F. SeguraXue ZhangGuohong HuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingyi Yu Rong Lei Xueqian Zhuang Xiaoxun Li Gang Li Sima Lev Miguel F. Segura Xue Zhang Guohong Hu MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
description	SMAD7 is a transcriptional target and a negative regulator of TGFβ signalling forming a negative feedback loop. Here the authors show that in cancer cells TGFβ activates the expression of microRNA-182 that suppresses SMAD7 protein, promoting TGFβ-mediated breast tumour invasion and bone metastasis.
format	article
author	Jingyi Yu Rong Lei Xueqian Zhuang Xiaoxun Li Gang Li Sima Lev Miguel F. Segura Xue Zhang Guohong Hu
author_facet	Jingyi Yu Rong Lei Xueqian Zhuang Xiaoxun Li Gang Li Sima Lev Miguel F. Segura Xue Zhang Guohong Hu
author_sort	Jingyi Yu
title	MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_short	MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_full	MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_fullStr	MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_full_unstemmed	MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
title_sort	microrna-182 targets smad7 to potentiate tgfβ-induced epithelial-mesenchymal transition and metastasis of cancer cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ec0353b3c0b54b89a9b62aad167220c3
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MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

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