Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients

Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development. Very little research has been done on their f...

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Autores principales:	Vidinov K., Dodova R., Mitev P., Mitkova A., Dimitrova I., Shinkov A., Ivanova R., Mitev V., Kaneva R.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	papillary thyroid cancer braf nras snp rs2853669 tert Medicine R
Acceso en línea:	https://doaj.org/article/ec04b6dae9f843aaafce49eeb8c2ed30
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spelling	oai:doaj.org-article:ec04b6dae9f843aaafce49eeb8c2ed302021-12-02T19:05:13ZClinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients0324-175010.2478/amb-2021-0001https://doaj.org/article/ec04b6dae9f843aaafce49eeb8c2ed302021-04-01T00:00:00Zhttps://doi.org/10.2478/amb-2021-0001https://doaj.org/toc/0324-1750Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development. Very little research has been done on their frequency and clinical relevance in Bulgarian patients with papillary thyroid cancer (PTC). This study is focused on investigating somatic mutation frequency in Bulgarian patients with PTC and their association with clinicopathologic features.Vidinov K.Dodova R.Mitev P.Mitkova A.Dimitrova I.Shinkov A.Ivanova R.Mitev V.Kaneva R.Sciendoarticlepapillary thyroid cancerbrafnrassnp rs2853669tertMedicineRENActa Medica Bulgarica, Vol 48, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	papillary thyroid cancer braf nras snp rs2853669 tert Medicine R
spellingShingle	papillary thyroid cancer braf nras snp rs2853669 tert Medicine R Vidinov K. Dodova R. Mitev P. Mitkova A. Dimitrova I. Shinkov A. Ivanova R. Mitev V. Kaneva R. Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients
description	Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development. Very little research has been done on their frequency and clinical relevance in Bulgarian patients with papillary thyroid cancer (PTC). This study is focused on investigating somatic mutation frequency in Bulgarian patients with PTC and their association with clinicopathologic features.
format	article
author	Vidinov K. Dodova R. Mitev P. Mitkova A. Dimitrova I. Shinkov A. Ivanova R. Mitev V. Kaneva R.
author_facet	Vidinov K. Dodova R. Mitev P. Mitkova A. Dimitrova I. Shinkov A. Ivanova R. Mitev V. Kaneva R.
author_sort	Vidinov K.
title	Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients
title_short	Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients
title_full	Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients
title_fullStr	Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients
title_full_unstemmed	Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients
title_sort	clinicopathological significance of braf (v600e), nras (q61k) and tert (c228t, c250t and snp rs2853669) mutations in bulgarian papillary thyroid carcinoma patients
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/ec04b6dae9f843aaafce49eeb8c2ed30
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Clinicopathological Significance of BRAF (V600E), NRAS (Q61K) and TERT (C228T, C250T and SNP Rs2853669) Mutations in Bulgarian Papillary Thyroid Carcinoma Patients

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