Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by aggregation of Tau, encoded by MAPT. Here, the authors perform an EWAS for PSP in prefrontal lobe tissue and find hypermethylation of DLX1 and its antisense transcript DLX1AS to associate with MAPT expression.

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Auteurs principaux:	Axel Weber, Sigrid C. Schwarz, Jörg Tost, Dietrich Trümbach, Pia Winter, Florence Busato, Pawel Tacik, Anita C. Windhorst, Maud Fagny, Thomas Arzberger, Catriona McLean, John C. van Swieten, Johannes Schwarz, Daniela Vogt Weisenhorn, Wolfgang Wurst, Till Adhikary, Dennis W. Dickson, Günter U. Höglinger, Ulrich Müller
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/ec0d1bbe28a5442e9f538934be3dd2f3
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spelling	oai:doaj.org-article:ec0d1bbe28a5442e9f538934be3dd2f32021-12-02T14:38:48ZEpigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX110.1038/s41467-018-05325-y2041-1723https://doaj.org/article/ec0d1bbe28a5442e9f538934be3dd2f32018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05325-yhttps://doaj.org/toc/2041-1723Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by aggregation of Tau, encoded by MAPT. Here, the authors perform an EWAS for PSP in prefrontal lobe tissue and find hypermethylation of DLX1 and its antisense transcript DLX1AS to associate with MAPT expression.Axel WeberSigrid C. SchwarzJörg TostDietrich TrümbachPia WinterFlorence BusatoPawel TacikAnita C. WindhorstMaud FagnyThomas ArzbergerCatriona McLeanJohn C. van SwietenJohannes SchwarzDaniela Vogt WeisenhornWolfgang WurstTill AdhikaryDennis W. DicksonGünter U. HöglingerUlrich MüllerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Axel Weber Sigrid C. Schwarz Jörg Tost Dietrich Trümbach Pia Winter Florence Busato Pawel Tacik Anita C. Windhorst Maud Fagny Thomas Arzberger Catriona McLean John C. van Swieten Johannes Schwarz Daniela Vogt Weisenhorn Wolfgang Wurst Till Adhikary Dennis W. Dickson Günter U. Höglinger Ulrich Müller Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1
description	Progressive supranuclear palsy (PSP) is a neurodegenerative disease characterized by aggregation of Tau, encoded by MAPT. Here, the authors perform an EWAS for PSP in prefrontal lobe tissue and find hypermethylation of DLX1 and its antisense transcript DLX1AS to associate with MAPT expression.
format	article
author	Axel Weber Sigrid C. Schwarz Jörg Tost Dietrich Trümbach Pia Winter Florence Busato Pawel Tacik Anita C. Windhorst Maud Fagny Thomas Arzberger Catriona McLean John C. van Swieten Johannes Schwarz Daniela Vogt Weisenhorn Wolfgang Wurst Till Adhikary Dennis W. Dickson Günter U. Höglinger Ulrich Müller
author_facet	Axel Weber Sigrid C. Schwarz Jörg Tost Dietrich Trümbach Pia Winter Florence Busato Pawel Tacik Anita C. Windhorst Maud Fagny Thomas Arzberger Catriona McLean John C. van Swieten Johannes Schwarz Daniela Vogt Weisenhorn Wolfgang Wurst Till Adhikary Dennis W. Dickson Günter U. Höglinger Ulrich Müller
author_sort	Axel Weber
title	Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1
title_short	Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1
title_full	Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1
title_fullStr	Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1
title_full_unstemmed	Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1
title_sort	epigenome-wide dna methylation profiling in progressive supranuclear palsy reveals major changes at dlx1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ec0d1bbe28a5442e9f538934be3dd2f3
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Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1

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