The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease

Li Gu,1 Song Xue2 1Department of Endocrinology, People’s Hospital of Gaochun, Nanjing, 211300, People’s Republic of China; 2Department of Pathology, People’s Hospital of Gaochun, Nanjing, 211300, People’s Republic of ChinaCorrespondence: Li GuDepartment of Endocrinology, People’s Hospital of Gaochun...

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Autores principales:	Gu L, Xue S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	red cell distribution width diabetic chronic kidney disease correlation inflammation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ec0d1c8fc3cc487a96212dd06cae88d4
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spelling	oai:doaj.org-article:ec0d1c8fc3cc487a96212dd06cae88d42021-11-16T18:47:50ZThe Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease1178-7074https://doaj.org/article/ec0d1c8fc3cc487a96212dd06cae88d42021-11-01T00:00:00Zhttps://www.dovepress.com/the-association-between-red-blood-cell-distribution-width-and-the-seve-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Li Gu,1 Song Xue2 1Department of Endocrinology, People’s Hospital of Gaochun, Nanjing, 211300, People’s Republic of China; 2Department of Pathology, People’s Hospital of Gaochun, Nanjing, 211300, People’s Republic of ChinaCorrespondence: Li GuDepartment of Endocrinology, People’s Hospital of Gaochun, No. 53 Maoshan Road, Gaochun District Economic Development Zone, Nanjing, 211300, People’s Republic of ChinaTel +86 13851529447Email Rougu_doct@163.comPurpose: Red cell distribution width (RDW) has been evidenced to be related to various diabetes-associated macrovascular and microvascular complications. However, the studies on the association between RDW and diabetic chronic kidney disease (CKD) are still scarce. The aim of the study is to explore whether there is any association between RDW and the severity of diabetic CKD.Patients and Methods: The study recruited 396 patients diagnosed with diabetic CKD at People’s Hospital of Gaochun from January 2006 to April 2021. Baseline characteristics were gathered and laboratory tests were performed to measure clinical indexes. Patients were also categorized into three groups based on their CKD stages. Correlation analysis and multivariate ordinal logistic regression were performed to investigate the association between RDW and the severity of diabetic CKD. The risk size was described as odds ratio (OR) and 95% confidence interval (CI).Results: We found a significant association between RDW and the severity of CKD, with a correlation coefficient of 0.32 (P < 0.01). We used three models for multivariate ordinal logistic regression to investigate the relationship between RDW and the severity of CKD. Results showed that RDW is an independent and significant risk factor of diabetic CKD after adjustment for demographic data, physiological indexes, and drug history [Model 3 OR (95% CI) = 1.225 (1.023– 1.467)]. In subgroup analysis, RDW remained a significant risk factor in all three models for patients who had diabetes of 5– 10 years [Model 3 OR (95% CI) = 1.480 (1.067– 2.052)] and had a HbA1c level > 7% [(Model 3 OR (95% CI) = 1.478 (1.184– 1.845)].Conclusion: RDW is significantly associated with the disease stages of diabetic CKD, and the risk is higher for people with 5– 10 years of diabetes and for those who do not control the HbA1c level well. This study has implications for the diagnosis, monitoring, and timely treatment of the diabetic CKD.Keywords: red cell distribution width, diabetic chronic kidney disease, correlation, inflammationGu LXue SDove Medical Pressarticlered cell distribution widthdiabetic chronic kidney diseasecorrelationinflammationMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8355-8363 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	red cell distribution width diabetic chronic kidney disease correlation inflammation Medicine (General) R5-920
spellingShingle	red cell distribution width diabetic chronic kidney disease correlation inflammation Medicine (General) R5-920 Gu L Xue S The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease
description	Li Gu,1 Song Xue2 1Department of Endocrinology, People’s Hospital of Gaochun, Nanjing, 211300, People’s Republic of China; 2Department of Pathology, People’s Hospital of Gaochun, Nanjing, 211300, People’s Republic of ChinaCorrespondence: Li GuDepartment of Endocrinology, People’s Hospital of Gaochun, No. 53 Maoshan Road, Gaochun District Economic Development Zone, Nanjing, 211300, People’s Republic of ChinaTel +86 13851529447Email Rougu_doct@163.comPurpose: Red cell distribution width (RDW) has been evidenced to be related to various diabetes-associated macrovascular and microvascular complications. However, the studies on the association between RDW and diabetic chronic kidney disease (CKD) are still scarce. The aim of the study is to explore whether there is any association between RDW and the severity of diabetic CKD.Patients and Methods: The study recruited 396 patients diagnosed with diabetic CKD at People’s Hospital of Gaochun from January 2006 to April 2021. Baseline characteristics were gathered and laboratory tests were performed to measure clinical indexes. Patients were also categorized into three groups based on their CKD stages. Correlation analysis and multivariate ordinal logistic regression were performed to investigate the association between RDW and the severity of diabetic CKD. The risk size was described as odds ratio (OR) and 95% confidence interval (CI).Results: We found a significant association between RDW and the severity of CKD, with a correlation coefficient of 0.32 (P < 0.01). We used three models for multivariate ordinal logistic regression to investigate the relationship between RDW and the severity of CKD. Results showed that RDW is an independent and significant risk factor of diabetic CKD after adjustment for demographic data, physiological indexes, and drug history [Model 3 OR (95% CI) = 1.225 (1.023– 1.467)]. In subgroup analysis, RDW remained a significant risk factor in all three models for patients who had diabetes of 5– 10 years [Model 3 OR (95% CI) = 1.480 (1.067– 2.052)] and had a HbA1c level > 7% [(Model 3 OR (95% CI) = 1.478 (1.184– 1.845)].Conclusion: RDW is significantly associated with the disease stages of diabetic CKD, and the risk is higher for people with 5– 10 years of diabetes and for those who do not control the HbA1c level well. This study has implications for the diagnosis, monitoring, and timely treatment of the diabetic CKD.Keywords: red cell distribution width, diabetic chronic kidney disease, correlation, inflammation
format	article
author	Gu L Xue S
author_facet	Gu L Xue S
author_sort	Gu L
title	The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease
title_short	The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease
title_full	The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease
title_fullStr	The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease
title_full_unstemmed	The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease
title_sort	association between red blood cell distribution width and the severity of diabetic chronic kidney disease
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ec0d1c8fc3cc487a96212dd06cae88d4
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The Association Between Red Blood Cell Distribution Width and the Severity of Diabetic Chronic Kidney Disease

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