Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma
The tumour microenvironment (TME) has a major role in chemoresistance in multiple myeloma. The authors show that a nanoparticle targeted to TME and loaded with bortezomib (BTZ) and Y27632 is more effective than free drugs, non-targeted and single-agent controls and reduces BTZ-related side effects.
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Nature Portfolio
2020
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oai:doaj.org-article:ec116aa5de4e46b1b6f2162c28d0c6892021-12-02T17:31:54ZTumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma10.1038/s41467-020-19932-12041-1723https://doaj.org/article/ec116aa5de4e46b1b6f2162c28d0c6892020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19932-1https://doaj.org/toc/2041-1723The tumour microenvironment (TME) has a major role in chemoresistance in multiple myeloma. The authors show that a nanoparticle targeted to TME and loaded with bortezomib (BTZ) and Y27632 is more effective than free drugs, non-targeted and single-agent controls and reduces BTZ-related side effects.Cinzia FedericoKinan AlhallakJennifer SunKathleen DuncanFeda AzabGail P. SudlowPilar de la PuenteBarbara MuzVaishali KapoorLuna ZhangFangzheng YuanMatea MarkovicJoseph KotsybarKatherine WasdenNicole GuenthnerShannon GurleyJustin KingDaniel KohnenNoha N. SalamaDinesh ThotalaDennis E. HallahanRavi VijJohn F. DiPersioSamuel AchilefuAbdel Kareem AzabNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Cinzia Federico Kinan Alhallak Jennifer Sun Kathleen Duncan Feda Azab Gail P. Sudlow Pilar de la Puente Barbara Muz Vaishali Kapoor Luna Zhang Fangzheng Yuan Matea Markovic Joseph Kotsybar Katherine Wasden Nicole Guenthner Shannon Gurley Justin King Daniel Kohnen Noha N. Salama Dinesh Thotala Dennis E. Hallahan Ravi Vij John F. DiPersio Samuel Achilefu Abdel Kareem Azab Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma |
| description |
The tumour microenvironment (TME) has a major role in chemoresistance in multiple myeloma. The authors show that a nanoparticle targeted to TME and loaded with bortezomib (BTZ) and Y27632 is more effective than free drugs, non-targeted and single-agent controls and reduces BTZ-related side effects. |
| format |
article |
| author |
Cinzia Federico Kinan Alhallak Jennifer Sun Kathleen Duncan Feda Azab Gail P. Sudlow Pilar de la Puente Barbara Muz Vaishali Kapoor Luna Zhang Fangzheng Yuan Matea Markovic Joseph Kotsybar Katherine Wasden Nicole Guenthner Shannon Gurley Justin King Daniel Kohnen Noha N. Salama Dinesh Thotala Dennis E. Hallahan Ravi Vij John F. DiPersio Samuel Achilefu Abdel Kareem Azab |
| author_facet |
Cinzia Federico Kinan Alhallak Jennifer Sun Kathleen Duncan Feda Azab Gail P. Sudlow Pilar de la Puente Barbara Muz Vaishali Kapoor Luna Zhang Fangzheng Yuan Matea Markovic Joseph Kotsybar Katherine Wasden Nicole Guenthner Shannon Gurley Justin King Daniel Kohnen Noha N. Salama Dinesh Thotala Dennis E. Hallahan Ravi Vij John F. DiPersio Samuel Achilefu Abdel Kareem Azab |
| author_sort |
Cinzia Federico |
| title |
Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma |
| title_short |
Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma |
| title_full |
Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma |
| title_fullStr |
Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma |
| title_full_unstemmed |
Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma |
| title_sort |
tumor microenvironment-targeted nanoparticles loaded with bortezomib and rock inhibitor improve efficacy in multiple myeloma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ec116aa5de4e46b1b6f2162c28d0c689 |
| work_keys_str_mv |
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