Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes

Interferon (IFN) is an important component of antiviral immunity, but can also be exploited by bacteria for immune evasion. Here the authors show that Listeria monocytogenes (Lm) induces type I IFN to suppress the degradation of Lm virulence proteins, ActA and LLO, and promote Lm infection in an IFI...

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Autores principales:	Joel M. J. Tan, Monica E. Garner, James M. Regeimbal, Catherine J. Greene, Jorge D. Rojas Márquez, Dustin A. Ammendolia, Adam R. R. McCluggage, Taoyingnan Li, Katherine J. Wu, Marija Cemma, Philip P. Ostrowski, Brian Raught, Michael S. Diamond, Sergio Grinstein, Robin M. Yates, Darren E. Higgins, John H. Brumell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec11a9708c984975be93768c9db2c7f1
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spelling	oai:doaj.org-article:ec11a9708c984975be93768c9db2c7f12021-12-02T15:10:40ZListeria exploits IFITM3 to suppress antibacterial activity in phagocytes10.1038/s41467-021-24982-02041-1723https://doaj.org/article/ec11a9708c984975be93768c9db2c7f12021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24982-0https://doaj.org/toc/2041-1723Interferon (IFN) is an important component of antiviral immunity, but can also be exploited by bacteria for immune evasion. Here the authors show that Listeria monocytogenes (Lm) induces type I IFN to suppress the degradation of Lm virulence proteins, ActA and LLO, and promote Lm infection in an IFITM3-dependent manner, thereby hinting at a potential target for antimicrobial therapy.Joel M. J. TanMonica E. GarnerJames M. RegeimbalCatherine J. GreeneJorge D. Rojas MárquezDustin A. AmmendoliaAdam R. R. McCluggageTaoyingnan LiKatherine J. WuMarija CemmaPhilip P. OstrowskiBrian RaughtMichael S. DiamondSergio GrinsteinRobin M. YatesDarren E. HigginsJohn H. BrumellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joel M. J. Tan Monica E. Garner James M. Regeimbal Catherine J. Greene Jorge D. Rojas Márquez Dustin A. Ammendolia Adam R. R. McCluggage Taoyingnan Li Katherine J. Wu Marija Cemma Philip P. Ostrowski Brian Raught Michael S. Diamond Sergio Grinstein Robin M. Yates Darren E. Higgins John H. Brumell Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
description	Interferon (IFN) is an important component of antiviral immunity, but can also be exploited by bacteria for immune evasion. Here the authors show that Listeria monocytogenes (Lm) induces type I IFN to suppress the degradation of Lm virulence proteins, ActA and LLO, and promote Lm infection in an IFITM3-dependent manner, thereby hinting at a potential target for antimicrobial therapy.
format	article
author	Joel M. J. Tan Monica E. Garner James M. Regeimbal Catherine J. Greene Jorge D. Rojas Márquez Dustin A. Ammendolia Adam R. R. McCluggage Taoyingnan Li Katherine J. Wu Marija Cemma Philip P. Ostrowski Brian Raught Michael S. Diamond Sergio Grinstein Robin M. Yates Darren E. Higgins John H. Brumell
author_facet	Joel M. J. Tan Monica E. Garner James M. Regeimbal Catherine J. Greene Jorge D. Rojas Márquez Dustin A. Ammendolia Adam R. R. McCluggage Taoyingnan Li Katherine J. Wu Marija Cemma Philip P. Ostrowski Brian Raught Michael S. Diamond Sergio Grinstein Robin M. Yates Darren E. Higgins John H. Brumell
author_sort	Joel M. J. Tan
title	Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
title_short	Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
title_full	Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
title_fullStr	Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
title_full_unstemmed	Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes
title_sort	listeria exploits ifitm3 to suppress antibacterial activity in phagocytes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec11a9708c984975be93768c9db2c7f1
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Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes

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