Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study

Objective To investigate long-term and serial functional outcomes in ischemic stroke patients without diabetes with post-stroke hyperglycemia. Methods The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) is a large, multi-center, prospective cohort study of stroke patients admitted to...

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Autores principales:	Jin A Yoon, Yong-Il Shin, Deog Young Kim, Min Kyun Sohn, Jongmin Lee, Sam-Gyu Lee, Yang-Soo Lee, Eun Young Han, Min Cheol Joo, Gyung-Jae Oh, Minsu Park, Won Hyuk Chang, Yun-Hee Kim
Formato:	article
Lenguaje:	EN
Publicado:	Korean Academy of Rehabilitation Medicine 2021
Materias:	cohort studies recovery of function ischemic stroke hyperglycemia Medicine R
Acceso en línea:	https://doaj.org/article/ec1204b9131f4b3bbf36081ead7fb5f8
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spelling	oai:doaj.org-article:ec1204b9131f4b3bbf36081ead7fb5f82021-11-05T02:27:48ZPost-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study2234-06452234-065310.5535/arm.21124https://doaj.org/article/ec1204b9131f4b3bbf36081ead7fb5f82021-10-01T00:00:00Zhttp://www.e-arm.org/upload/pdf/arm-21124.pdfhttps://doaj.org/toc/2234-0645https://doaj.org/toc/2234-0653Objective To investigate long-term and serial functional outcomes in ischemic stroke patients without diabetes with post-stroke hyperglycemia. Methods The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) is a large, multi-center, prospective cohort study of stroke patients admitted to participating hospitals in nine areas of Korea. From KOSCO, ischemic stroke patients without diabetes were recruited and divided into two groups: patients without diabetes without (n=779) and with post-stroke hyperglycemia (n=223). Post-stroke hyperglycemia was defined as a glucose level >8 mmol/L. Functional assessments were performed 7 days and 3, 6, and 12 months after stroke onset. Results There were no significant differences in baseline characteristics between the groups, except in the age of onset and smoking. Analysis of the linear correlation between the initial National Institutes of Health Stroke Scale (NIHSS) score and glucose level showed no significant difference. Among our functional assessments, NIHSS, Fugl-Meyer Assessment (affected side), Functional Ambulatory Category, modified Rankin Scale, and Korean Mini-Mental State Examination (K-MMSE) showed statistically significant improvements in each group. All functional improvements except K-MMSE were significantly higher in patients without post-stroke hyperglycemia at 7 days and 3, 6, and 12 months. Conclusion The glucose level of ischemic stroke patients without diabetes had no significant correlation with the initial NIHSS score. The long-term effects of stress hyperglycemia showed worse functional outcomes in ischemic stroke patients without diabetes with post-stroke hyperglycemia.Jin A YoonYong-Il ShinDeog Young KimMin Kyun SohnJongmin LeeSam-Gyu LeeYang-Soo LeeEun Young HanMin Cheol JooGyung-Jae OhMinsu ParkWon Hyuk ChangYun-Hee KimKorean Academy of Rehabilitation Medicinearticlecohort studiesrecovery of functionischemic strokehyperglycemiaMedicineRENAnnals of Rehabilitation Medicine, Vol 45, Iss 5, Pp 359-367 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cohort studies recovery of function ischemic stroke hyperglycemia Medicine R
spellingShingle	cohort studies recovery of function ischemic stroke hyperglycemia Medicine R Jin A Yoon Yong-Il Shin Deog Young Kim Min Kyun Sohn Jongmin Lee Sam-Gyu Lee Yang-Soo Lee Eun Young Han Min Cheol Joo Gyung-Jae Oh Minsu Park Won Hyuk Chang Yun-Hee Kim Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study
description	Objective To investigate long-term and serial functional outcomes in ischemic stroke patients without diabetes with post-stroke hyperglycemia. Methods The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) is a large, multi-center, prospective cohort study of stroke patients admitted to participating hospitals in nine areas of Korea. From KOSCO, ischemic stroke patients without diabetes were recruited and divided into two groups: patients without diabetes without (n=779) and with post-stroke hyperglycemia (n=223). Post-stroke hyperglycemia was defined as a glucose level >8 mmol/L. Functional assessments were performed 7 days and 3, 6, and 12 months after stroke onset. Results There were no significant differences in baseline characteristics between the groups, except in the age of onset and smoking. Analysis of the linear correlation between the initial National Institutes of Health Stroke Scale (NIHSS) score and glucose level showed no significant difference. Among our functional assessments, NIHSS, Fugl-Meyer Assessment (affected side), Functional Ambulatory Category, modified Rankin Scale, and Korean Mini-Mental State Examination (K-MMSE) showed statistically significant improvements in each group. All functional improvements except K-MMSE were significantly higher in patients without post-stroke hyperglycemia at 7 days and 3, 6, and 12 months. Conclusion The glucose level of ischemic stroke patients without diabetes had no significant correlation with the initial NIHSS score. The long-term effects of stress hyperglycemia showed worse functional outcomes in ischemic stroke patients without diabetes with post-stroke hyperglycemia.
format	article
author	Jin A Yoon Yong-Il Shin Deog Young Kim Min Kyun Sohn Jongmin Lee Sam-Gyu Lee Yang-Soo Lee Eun Young Han Min Cheol Joo Gyung-Jae Oh Minsu Park Won Hyuk Chang Yun-Hee Kim
author_facet	Jin A Yoon Yong-Il Shin Deog Young Kim Min Kyun Sohn Jongmin Lee Sam-Gyu Lee Yang-Soo Lee Eun Young Han Min Cheol Joo Gyung-Jae Oh Minsu Park Won Hyuk Chang Yun-Hee Kim
author_sort	Jin A Yoon
title	Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study
title_short	Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study
title_full	Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study
title_fullStr	Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study
title_full_unstemmed	Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study
title_sort	post-stroke hyperglycemia in non-diabetic ischemic stroke is related with worse functional outcome: a cohort study
publisher	Korean Academy of Rehabilitation Medicine
publishDate	2021
url	https://doaj.org/article/ec1204b9131f4b3bbf36081ead7fb5f8
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Post-stroke Hyperglycemia in Non-diabetic Ischemic Stroke is Related With Worse Functional Outcome: A Cohort Study

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