Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with repetitive and restrictive behaviours. Here the authors integrate mRNA expression, miRNA expression, DNA methylation, and histone acetylation datasets from a collection of post mortem b...

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Autores principales:	Gokul Ramaswami, Hyejung Won, Michael J. Gandal, Jillian Haney, Jerry C. Wang, Chloe C. Y. Wong, Wenjie Sun, Shyam Prabhakar, Jonathan Mill, Daniel H. Geschwind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec12151260b7497e96f2462d590b22b5
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spelling	oai:doaj.org-article:ec12151260b7497e96f2462d590b22b52021-12-02T17:27:20ZIntegrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism10.1038/s41467-020-18526-12041-1723https://doaj.org/article/ec12151260b7497e96f2462d590b22b52020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18526-1https://doaj.org/toc/2041-1723Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with repetitive and restrictive behaviours. Here the authors integrate mRNA expression, miRNA expression, DNA methylation, and histone acetylation datasets from a collection of post mortem brain tissues and identify a convergent molecular subtype of ASD.Gokul RamaswamiHyejung WonMichael J. GandalJillian HaneyJerry C. WangChloe C. Y. WongWenjie SunShyam PrabhakarJonathan MillDaniel H. GeschwindNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gokul Ramaswami Hyejung Won Michael J. Gandal Jillian Haney Jerry C. Wang Chloe C. Y. Wong Wenjie Sun Shyam Prabhakar Jonathan Mill Daniel H. Geschwind Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
description	Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions with repetitive and restrictive behaviours. Here the authors integrate mRNA expression, miRNA expression, DNA methylation, and histone acetylation datasets from a collection of post mortem brain tissues and identify a convergent molecular subtype of ASD.
format	article
author	Gokul Ramaswami Hyejung Won Michael J. Gandal Jillian Haney Jerry C. Wang Chloe C. Y. Wong Wenjie Sun Shyam Prabhakar Jonathan Mill Daniel H. Geschwind
author_facet	Gokul Ramaswami Hyejung Won Michael J. Gandal Jillian Haney Jerry C. Wang Chloe C. Y. Wong Wenjie Sun Shyam Prabhakar Jonathan Mill Daniel H. Geschwind
author_sort	Gokul Ramaswami
title	Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
title_short	Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
title_full	Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
title_fullStr	Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
title_full_unstemmed	Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
title_sort	integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ec12151260b7497e96f2462d590b22b5
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Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism

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