Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV

Abstract The use of marijuana is highly prevalent among young men who have sex with men (YMSM). Past work has also shown that inflammation is elevated among YMSM, independent of HIV status. Here, we aim to examine the relationship between marijuana use and inflammation among this high-risk cohort, r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ethan Morgan, Hannah Hudson, Richard D’Aquila, Brian Mustanski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec12b3e0013a4e459bd61b050f85f7a1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ec12b3e0013a4e459bd61b050f85f7a1
record_format	dspace
spelling	oai:doaj.org-article:ec12b3e0013a4e459bd61b050f85f7a12021-12-02T15:54:09ZPlasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV10.1038/s41598-021-84352-02045-2322https://doaj.org/article/ec12b3e0013a4e459bd61b050f85f7a12021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84352-0https://doaj.org/toc/2045-2322Abstract The use of marijuana is highly prevalent among young men who have sex with men (YMSM). Past work has also shown that inflammation is elevated among YMSM, independent of HIV status. Here, we aim to examine the relationship between marijuana use and inflammation among this high-risk cohort, relative to use of other substances. Data were collected among YMSM aged 16–29 in Chicago. Multiplex cytokine and inflammatory biomarker assays were run on plasma from all persons living with HIV (PLWH) (n = 195) and a subset of HIV-negative participants (n = 489). Bivariate analyses and multivariable models assessed relationships between various substances and inflammatory biomarkers. Models were stratified by HIV status and adjusted for demographic characteristics. Most participants reported use of marijuana in the past 30 days (416, 60.8%). Mean blood C-reactive protein (CRP) levels were above the upper limit of normal (3.0 mg/L), indicative of increased risk for cardiovascular disease (mean CRP was 3.9 mg/L; SD = 8.5). In adjusted, stratified analyses, CRP was significantly lower among participants reporting frequent marijuana use (≥ 6 times per month), relative to those reporting never using marijuana, (β = − 0.38; 95% CI: − 0.73, − 0.03). However, this was entirely accounted for by an association among the HIV-negative participants and there was no significant association between marijuana use and blood CRP level among the PLWH. In summary, YMSM had markedly elevated marijuana use and blood CRP levels. Frequent marijuana use was associated with lower inflammation among only those not diagnosed with HIV. Further research is needed to explicate why there are differences between HIV-negative participants and PLWH and to leverage this information to characterize biological mechanisms by which marijuana decreases inflammation.Ethan MorganHannah HudsonRichard D’AquilaBrian MustanskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ethan Morgan Hannah Hudson Richard D’Aquila Brian Mustanski Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV
description	Abstract The use of marijuana is highly prevalent among young men who have sex with men (YMSM). Past work has also shown that inflammation is elevated among YMSM, independent of HIV status. Here, we aim to examine the relationship between marijuana use and inflammation among this high-risk cohort, relative to use of other substances. Data were collected among YMSM aged 16–29 in Chicago. Multiplex cytokine and inflammatory biomarker assays were run on plasma from all persons living with HIV (PLWH) (n = 195) and a subset of HIV-negative participants (n = 489). Bivariate analyses and multivariable models assessed relationships between various substances and inflammatory biomarkers. Models were stratified by HIV status and adjusted for demographic characteristics. Most participants reported use of marijuana in the past 30 days (416, 60.8%). Mean blood C-reactive protein (CRP) levels were above the upper limit of normal (3.0 mg/L), indicative of increased risk for cardiovascular disease (mean CRP was 3.9 mg/L; SD = 8.5). In adjusted, stratified analyses, CRP was significantly lower among participants reporting frequent marijuana use (≥ 6 times per month), relative to those reporting never using marijuana, (β = − 0.38; 95% CI: − 0.73, − 0.03). However, this was entirely accounted for by an association among the HIV-negative participants and there was no significant association between marijuana use and blood CRP level among the PLWH. In summary, YMSM had markedly elevated marijuana use and blood CRP levels. Frequent marijuana use was associated with lower inflammation among only those not diagnosed with HIV. Further research is needed to explicate why there are differences between HIV-negative participants and PLWH and to leverage this information to characterize biological mechanisms by which marijuana decreases inflammation.
format	article
author	Ethan Morgan Hannah Hudson Richard D’Aquila Brian Mustanski
author_facet	Ethan Morgan Hannah Hudson Richard D’Aquila Brian Mustanski
author_sort	Ethan Morgan
title	Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV
title_short	Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV
title_full	Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV
title_fullStr	Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV
title_full_unstemmed	Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV
title_sort	plasma c-reactive protein is lower among marijuana using hiv-negative individuals but not among persons living with hiv
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec12b3e0013a4e459bd61b050f85f7a1
work_keys_str_mv	AT ethanmorgan plasmacreactiveproteinisloweramongmarijuanausinghivnegativeindividualsbutnotamongpersonslivingwithhiv AT hannahhudson plasmacreactiveproteinisloweramongmarijuanausinghivnegativeindividualsbutnotamongpersonslivingwithhiv AT richarddaquila plasmacreactiveproteinisloweramongmarijuanausinghivnegativeindividualsbutnotamongpersonslivingwithhiv AT brianmustanski plasmacreactiveproteinisloweramongmarijuanausinghivnegativeindividualsbutnotamongpersonslivingwithhiv
_version_	1718385485422788608

Plasma C-reactive protein is lower among marijuana using HIV-negative individuals but not among persons living with HIV

Ejemplares similares