Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling may inform immunotherapy approaches in paediatric pa...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yura Grabovska, Alan Mackay, Patricia O’Hare, Stephen Crosier, Martina Finetti, Edward C. Schwalbe, Jessica C. Pickles, Amy R. Fairchild, Aimee Avery, Julia Cockle, Rebecca Hill, Janet Lindsey, Debbie Hicks, Mark Kristiansen, Jane Chalker, John Anderson, Darren Hargrave, Thomas S. Jacques, Karin Straathof, Simon Bailey, Chris Jones, Steven C. Clifford, Daniel Williamson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ec15b2c4e08f447294d1c85b886169aa
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:ec15b2c4e08f447294d1c85b886169aa
record_format dspace
spelling oai:doaj.org-article:ec15b2c4e08f447294d1c85b886169aa2021-12-02T15:09:25ZPediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity10.1038/s41467-020-18070-y2041-1723https://doaj.org/article/ec15b2c4e08f447294d1c85b886169aa2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18070-yhttps://doaj.org/toc/2041-1723Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling may inform immunotherapy approaches in paediatric patients with CNS tumour.Yura GrabovskaAlan MackayPatricia O’HareStephen CrosierMartina FinettiEdward C. SchwalbeJessica C. PicklesAmy R. FairchildAimee AveryJulia CockleRebecca HillJanet LindseyDebbie HicksMark KristiansenJane ChalkerJohn AndersonDarren HargraveThomas S. JacquesKarin StraathofSimon BaileyChris JonesSteven C. CliffordDaniel WilliamsonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yura Grabovska
Alan Mackay
Patricia O’Hare
Stephen Crosier
Martina Finetti
Edward C. Schwalbe
Jessica C. Pickles
Amy R. Fairchild
Aimee Avery
Julia Cockle
Rebecca Hill
Janet Lindsey
Debbie Hicks
Mark Kristiansen
Jane Chalker
John Anderson
Darren Hargrave
Thomas S. Jacques
Karin Straathof
Simon Bailey
Chris Jones
Steven C. Clifford
Daniel Williamson
Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
description Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling may inform immunotherapy approaches in paediatric patients with CNS tumour.
format article
author Yura Grabovska
Alan Mackay
Patricia O’Hare
Stephen Crosier
Martina Finetti
Edward C. Schwalbe
Jessica C. Pickles
Amy R. Fairchild
Aimee Avery
Julia Cockle
Rebecca Hill
Janet Lindsey
Debbie Hicks
Mark Kristiansen
Jane Chalker
John Anderson
Darren Hargrave
Thomas S. Jacques
Karin Straathof
Simon Bailey
Chris Jones
Steven C. Clifford
Daniel Williamson
author_facet Yura Grabovska
Alan Mackay
Patricia O’Hare
Stephen Crosier
Martina Finetti
Edward C. Schwalbe
Jessica C. Pickles
Amy R. Fairchild
Aimee Avery
Julia Cockle
Rebecca Hill
Janet Lindsey
Debbie Hicks
Mark Kristiansen
Jane Chalker
John Anderson
Darren Hargrave
Thomas S. Jacques
Karin Straathof
Simon Bailey
Chris Jones
Steven C. Clifford
Daniel Williamson
author_sort Yura Grabovska
title Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
title_short Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
title_full Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
title_fullStr Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
title_full_unstemmed Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
title_sort pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ec15b2c4e08f447294d1c85b886169aa
work_keys_str_mv AT yuragrabovska pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT alanmackay pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT patriciaohare pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT stephencrosier pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT martinafinetti pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT edwardcschwalbe pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT jessicacpickles pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT amyrfairchild pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT aimeeavery pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT juliacockle pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT rebeccahill pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT janetlindsey pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT debbiehicks pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT markkristiansen pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT janechalker pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT johnanderson pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT darrenhargrave pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT thomassjacques pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT karinstraathof pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT simonbailey pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT chrisjones pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT stevencclifford pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
AT danielwilliamson pediatricpancentralnervoussystemtumoranalysisofimmunecellinfiltrationidentifiescorrelatesofantitumorimmunity
_version_ 1718387850167189504

Ejemplares similares