Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer

Abstract To compare in patients with untreated rectal cancer quantitative perfusion parameters calculated from 3rd-generation dual-source dynamic volume perfusion CT (dVPCT) with 3-Tesla-MR-perfusion with regard to data variability and tumour differentiation. In MR-perfusion, plasma flow (PF), plasm...

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Autores principales:	Sonja Sudarski, Thomas Henzler, Teresa Floss, Tanja Gaa, Mathias Meyer, Holger Haubenreisser, Stefan O. Schoenberg, Ulrike I. Attenberger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec17297c1ff440409d9cb9b4ec58f206
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spelling	oai:doaj.org-article:ec17297c1ff440409d9cb9b4ec58f2062021-12-02T15:08:53ZVariability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer10.1038/s41598-018-25307-w2045-2322https://doaj.org/article/ec17297c1ff440409d9cb9b4ec58f2062018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25307-whttps://doaj.org/toc/2045-2322Abstract To compare in patients with untreated rectal cancer quantitative perfusion parameters calculated from 3rd-generation dual-source dynamic volume perfusion CT (dVPCT) with 3-Tesla-MR-perfusion with regard to data variability and tumour differentiation. In MR-perfusion, plasma flow (PF), plasma volume (PV) and mean transit time (MTT) were assessed in two measurements (M1 and M2) by the same reader. In dVPCT, blood flow (BF), blood volume (BV), MTT and permeability (PERM) were assessed respectively. CT dose values were calculated. 20 patients (60 ± 13 years) were analysed. Intra-individual and intra-reader variability of duplicate MR-perfusion measurements was higher compared to duplicate dVPCT measurements. dVPCT-derived BF, BV and PERM could differentiate between tumour and normal rectal wall (significance level for M1 and M2, respectively, regarding BF: p < 0.0001/0.0001; BV: p < 0.0001/0.0001; MTT: p = 0.93/0.39; PERM: p < 0.0001/0.0001), with MR-perfusion this was true for PF and PV (p-values M1/M2 for PF: p = 0.04/0.01; PV: p = 0.002/0.003; MTT: p = 0.70/0.27*). Mean effective dose of CT-staging incl. dVPCT was 29 ± 6 mSv (20 ± 5 mSv for dVPCT alone). In conclusion, dVPCT has a lower data variability than MR-perfusion while both dVPCT and MR-perfusion could differentiate tumour tissue from normal rectal wall. With 3rd-generation dual-source CT dVPCT could be included in a standard CT-staging without exceeding national dose reference values.Sonja SudarskiThomas HenzlerTeresa FlossTanja GaaMathias MeyerHolger HaubenreisserStefan O. SchoenbergUlrike I. AttenbergerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sonja Sudarski Thomas Henzler Teresa Floss Tanja Gaa Mathias Meyer Holger Haubenreisser Stefan O. Schoenberg Ulrike I. Attenberger Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer
description	Abstract To compare in patients with untreated rectal cancer quantitative perfusion parameters calculated from 3rd-generation dual-source dynamic volume perfusion CT (dVPCT) with 3-Tesla-MR-perfusion with regard to data variability and tumour differentiation. In MR-perfusion, plasma flow (PF), plasma volume (PV) and mean transit time (MTT) were assessed in two measurements (M1 and M2) by the same reader. In dVPCT, blood flow (BF), blood volume (BV), MTT and permeability (PERM) were assessed respectively. CT dose values were calculated. 20 patients (60 ± 13 years) were analysed. Intra-individual and intra-reader variability of duplicate MR-perfusion measurements was higher compared to duplicate dVPCT measurements. dVPCT-derived BF, BV and PERM could differentiate between tumour and normal rectal wall (significance level for M1 and M2, respectively, regarding BF: p < 0.0001/0.0001; BV: p < 0.0001/0.0001; MTT: p = 0.93/0.39; PERM: p < 0.0001/0.0001), with MR-perfusion this was true for PF and PV (p-values M1/M2 for PF: p = 0.04/0.01; PV: p = 0.002/0.003; MTT: p = 0.70/0.27*). Mean effective dose of CT-staging incl. dVPCT was 29 ± 6 mSv (20 ± 5 mSv for dVPCT alone). In conclusion, dVPCT has a lower data variability than MR-perfusion while both dVPCT and MR-perfusion could differentiate tumour tissue from normal rectal wall. With 3rd-generation dual-source CT dVPCT could be included in a standard CT-staging without exceeding national dose reference values.
format	article
author	Sonja Sudarski Thomas Henzler Teresa Floss Tanja Gaa Mathias Meyer Holger Haubenreisser Stefan O. Schoenberg Ulrike I. Attenberger
author_facet	Sonja Sudarski Thomas Henzler Teresa Floss Tanja Gaa Mathias Meyer Holger Haubenreisser Stefan O. Schoenberg Ulrike I. Attenberger
author_sort	Sonja Sudarski
title	Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer
title_short	Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer
title_full	Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer
title_fullStr	Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer
title_full_unstemmed	Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer
title_sort	variability and reproducibility of 3rd-generation dual-source dynamic volume perfusion ct parameters in comparison to mr-perfusion parameters in rectal cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ec17297c1ff440409d9cb9b4ec58f206
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Variability and Reproducibility of 3rd-generation dual-source dynamic volume perfusion CT Parameters in Comparison to MR-perfusion Parameters in Rectal Cancer

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