The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype.
Indirect evidences suggest that acetylation phenotype categories are heterogeneous and that subcategories, related to specific NAT2 variant alleles might exist. We analyzed the in vivo acetylation phenotype and genotype in 504 north-American subjects of Caucasian origin. The analyses of the SNPs rs1...
Guardado en:
Autores principales: | Jhon D Ruiz, Carmen Martínez, Kristin Anderson, Myron Gross, Nicholas P Lang, Elena García-Martín, José A G Agúndez |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
|
Materias: | |
Acceso en línea: | https://doaj.org/article/ec17d7d5fb914c7e8726e7cdbb14c69a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients
por: Kelly S. Levano, et al.
Publicado: (2021) -
Structural basis of HypK regulating N-terminal acetylation by the NatA complex
por: Felix Alexander Weyer, et al.
Publicado: (2017) -
Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK
por: Sunbin Deng, et al.
Publicado: (2020) -
Defining eligible patients for allele-selective chemotherapies targeting NAT2 in colorectal cancer
por: Veronica Rendo, et al.
Publicado: (2020) -
Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates
por: Stephan Grunwald, et al.
Publicado: (2020)