Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine

Large protein machines are tightly regulated through allosteric communication channels. Here authors use single-molecule FRET and demonstrate the involvement of ultrafast conformational dynamics in the allosteric regulation of ClpB, a hexameric AAA+ machine that rescues aggregated proteins.

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Autores principales:	Hisham Mazal, Marija Iljina, Yoav Barak, Nadav Elad, Rina Rosenzweig, Pierre Goloubinoff, Inbal Riven, Gilad Haran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec18ad5b1e2047c382aaaf3a49e43f29
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spelling	oai:doaj.org-article:ec18ad5b1e2047c382aaaf3a49e43f292021-12-02T16:50:56ZTunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine10.1038/s41467-019-09474-62041-1723https://doaj.org/article/ec18ad5b1e2047c382aaaf3a49e43f292019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09474-6https://doaj.org/toc/2041-1723Large protein machines are tightly regulated through allosteric communication channels. Here authors use single-molecule FRET and demonstrate the involvement of ultrafast conformational dynamics in the allosteric regulation of ClpB, a hexameric AAA+ machine that rescues aggregated proteins.Hisham MazalMarija IljinaYoav BarakNadav EladRina RosenzweigPierre GoloubinoffInbal RivenGilad HaranNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hisham Mazal Marija Iljina Yoav Barak Nadav Elad Rina Rosenzweig Pierre Goloubinoff Inbal Riven Gilad Haran Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
description	Large protein machines are tightly regulated through allosteric communication channels. Here authors use single-molecule FRET and demonstrate the involvement of ultrafast conformational dynamics in the allosteric regulation of ClpB, a hexameric AAA+ machine that rescues aggregated proteins.
format	article
author	Hisham Mazal Marija Iljina Yoav Barak Nadav Elad Rina Rosenzweig Pierre Goloubinoff Inbal Riven Gilad Haran
author_facet	Hisham Mazal Marija Iljina Yoav Barak Nadav Elad Rina Rosenzweig Pierre Goloubinoff Inbal Riven Gilad Haran
author_sort	Hisham Mazal
title	Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
title_short	Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
title_full	Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
title_fullStr	Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
title_full_unstemmed	Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine
title_sort	tunable microsecond dynamics of an allosteric switch regulate the activity of a aaa+ disaggregation machine
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ec18ad5b1e2047c382aaaf3a49e43f29
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Tunable microsecond dynamics of an allosteric switch regulate the activity of a AAA+ disaggregation machine

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