АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS

The study included 90 patients with pulmonary tuberculosis who were divided into 3 groups, according to intensity and clinical form of the disease. Group 1 included 32 patients with infiltrative tuberculosis and two-segment pulmonary lesions; group 2, 31 patients with pulmonary tuberculoma, and grou...

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Autores principales:	S. N. Skorniakov, E. V. Sabadash, I. D. Medvinsky, B. I. Novikov, V. A. Pavlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	amino acids taurine glutathione monocytes pulmonary tuberculosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ec1c5eb183e6415e8b59d3e84da4e6bd
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spelling	oai:doaj.org-article:ec1c5eb183e6415e8b59d3e84da4e6bd2021-11-18T08:03:44ZАMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2015-1-75-80https://doaj.org/article/ec1c5eb183e6415e8b59d3e84da4e6bd2015-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/811https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study included 90 patients with pulmonary tuberculosis who were divided into 3 groups, according to intensity and clinical form of the disease. Group 1 included 32 patients with infiltrative tuberculosis and two-segment pulmonary lesions; group 2, 31 patients with pulmonary tuberculoma, and group 3, 27 patients with fibrous/cavernous tuberculosis for less than two years after the process stabilization. Group 4 represented a control (comparison) group of 30 healthy volunteers. The analysis showed that amino acid balance of monocytes in pulmonary tuberculosis can be, in general, characterized as deficient for antioxidant resources. In case of tuberculous inflammation, the criteria of specific resistance comprise a necessary taurine pool to greater extent than glutathione oxidation in immunocompetent cells. The plasma/monocyte taurine ratios exhibit different values, depending on clinical form of pulmonary tuberculosis. Redistribution of plasma amino acids to the monocytes, or, vice versa, probable “washout” certain amino acids from the cells may be considered a factor that reflects severity of the infectious process.S. N. SkorniakovE. V. SabadashI. D. MedvinskyB. I. NovikovV. A. PavlovSPb RAACIarticleamino acidstaurineglutathionemonocytespulmonary tuberculosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 1, Pp 75-80 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	amino acids taurine glutathione monocytes pulmonary tuberculosis Immunologic diseases. Allergy RC581-607
spellingShingle	amino acids taurine glutathione monocytes pulmonary tuberculosis Immunologic diseases. Allergy RC581-607 S. N. Skorniakov E. V. Sabadash I. D. Medvinsky B. I. Novikov V. A. Pavlov АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS
description	The study included 90 patients with pulmonary tuberculosis who were divided into 3 groups, according to intensity and clinical form of the disease. Group 1 included 32 patients with infiltrative tuberculosis and two-segment pulmonary lesions; group 2, 31 patients with pulmonary tuberculoma, and group 3, 27 patients with fibrous/cavernous tuberculosis for less than two years after the process stabilization. Group 4 represented a control (comparison) group of 30 healthy volunteers. The analysis showed that amino acid balance of monocytes in pulmonary tuberculosis can be, in general, characterized as deficient for antioxidant resources. In case of tuberculous inflammation, the criteria of specific resistance comprise a necessary taurine pool to greater extent than glutathione oxidation in immunocompetent cells. The plasma/monocyte taurine ratios exhibit different values, depending on clinical form of pulmonary tuberculosis. Redistribution of plasma amino acids to the monocytes, or, vice versa, probable “washout” certain amino acids from the cells may be considered a factor that reflects severity of the infectious process.
format	article
author	S. N. Skorniakov E. V. Sabadash I. D. Medvinsky B. I. Novikov V. A. Pavlov
author_facet	S. N. Skorniakov E. V. Sabadash I. D. Medvinsky B. I. Novikov V. A. Pavlov
author_sort	S. N. Skorniakov
title	АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS
title_short	АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS
title_full	АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS
title_fullStr	АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS
title_full_unstemmed	АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS
title_sort	аmino acid balance plasma and monocytes in patients with tuberculosis as a factor, reflects the severity of development of tuberculosis
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/ec1c5eb183e6415e8b59d3e84da4e6bd
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АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS

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