Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study

Jingjing Xu,1 Zhiyu Liu,2 Haitao Liu,1 Yunpeng Luo,3 Kai Kang,3 Xueting Li,1 Wei Yang,3 Dongsheng Fei,3 Changsong Wang,1,3 Kaijiang Yu3 1Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, People’s Republic of China; 2Department o...

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Autores principales:	Xu J, Liu Z, Liu H, Luo Y, Kang K, Li X, Yang W, Fei D, Wang C, Yu K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	covid-19 t lymphocytes pd-1 hla-dr redistribution. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/ec1ea104f69c4c2cb24b00ea37f763cc
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spelling	oai:doaj.org-article:ec1ea104f69c4c2cb24b00ea37f763cc2021-12-02T14:37:16ZDecreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study1178-7031https://doaj.org/article/ec1ea104f69c4c2cb24b00ea37f763cc2021-04-01T00:00:00Zhttps://www.dovepress.com/decreased-t-cell-levels-in-critically-ill-coronavirus-patients-single--peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Jingjing Xu,1 Zhiyu Liu,2 Haitao Liu,1 Yunpeng Luo,3 Kai Kang,3 Xueting Li,1 Wei Yang,3 Dongsheng Fei,3 Changsong Wang,1,3 Kaijiang Yu3 1Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, People’s Republic of China; 2Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 3Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of ChinaCorrespondence: Changsong WangDepartment of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, People’s Republic of ChinaEmail changsongwangicu@163.comKaijiang YuDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin, Heilongjiang Province, People’s Republic of ChinaEmail drkaijiang@163.comBackground: Since Dec. 2019, the COVID-19 pandemic has been an outbreak. T cells play an important role in dealing with various disease-causing pathogens. However, the role of T cells played in COVID-19 patients is still unknown. Our study aimed to describe the immunologic state of the critically ill COVID-19 patients.Methods: A total of 63 patients with confirmed COVID-19 pneumonia were admitted to the Department of Intensive Care Unit of the First Affiliated Hospital of Harbin Medical University. The immunologic characteristics (lymphocyte apoptosis, the expression of PD-1 and HLA-DR in T cells, T cell subset levels, redistribution and the production of inflammatory factors) as well as their laboratory parameters were compared between severe group and critical group.Results: The level of T cells in peripheral blood was decreased in critical patients compared with that in severe patients, but the expression levels of PD-1 (CD4+: 24.71% VS 30.56%; CD8+: 33.05% VS 32.38%) and HLA-DR (T cells: 36.28% VS 27.44%; monocytes: 20.58% VS 23.83%) in T cells were not significantly changed, and apoptosis and necrosis were not different in lymphocytes (apoptosis: 1.04% VS 1.27%; necrosis: 0.67% VS 1.11%), granulocytes, or monocytes between those two groups.Conclusion: There is severe immunosuppression in critically ill COVID-19 patients. Redistribution of T cells might be the main reason for lymphocytic decline. Decreasing the infiltration of T lymphocytes in the lung may be beneficial for the treatment of COVID-19.Keywords: COVID-19, T lymphocytes, PD-1, HLA-DR, redistributionXu JLiu ZLiu HLuo YKang KLi XYang WFei DWang CYu KDove Medical Pressarticlecovid-19t lymphocytespd-1hla-drredistribution.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 1331-1340 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 t lymphocytes pd-1 hla-dr redistribution. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	covid-19 t lymphocytes pd-1 hla-dr redistribution. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Xu J Liu Z Liu H Luo Y Kang K Li X Yang W Fei D Wang C Yu K Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study
description	Jingjing Xu,1 Zhiyu Liu,2 Haitao Liu,1 Yunpeng Luo,3 Kai Kang,3 Xueting Li,1 Wei Yang,3 Dongsheng Fei,3 Changsong Wang,1,3 Kaijiang Yu3 1Department of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, People’s Republic of China; 2Department of Laboratory Diagnostics, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 3Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of ChinaCorrespondence: Changsong WangDepartment of Critical Care Medicine, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province, People’s Republic of ChinaEmail changsongwangicu@163.comKaijiang YuDepartment of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin, Heilongjiang Province, People’s Republic of ChinaEmail drkaijiang@163.comBackground: Since Dec. 2019, the COVID-19 pandemic has been an outbreak. T cells play an important role in dealing with various disease-causing pathogens. However, the role of T cells played in COVID-19 patients is still unknown. Our study aimed to describe the immunologic state of the critically ill COVID-19 patients.Methods: A total of 63 patients with confirmed COVID-19 pneumonia were admitted to the Department of Intensive Care Unit of the First Affiliated Hospital of Harbin Medical University. The immunologic characteristics (lymphocyte apoptosis, the expression of PD-1 and HLA-DR in T cells, T cell subset levels, redistribution and the production of inflammatory factors) as well as their laboratory parameters were compared between severe group and critical group.Results: The level of T cells in peripheral blood was decreased in critical patients compared with that in severe patients, but the expression levels of PD-1 (CD4+: 24.71% VS 30.56%; CD8+: 33.05% VS 32.38%) and HLA-DR (T cells: 36.28% VS 27.44%; monocytes: 20.58% VS 23.83%) in T cells were not significantly changed, and apoptosis and necrosis were not different in lymphocytes (apoptosis: 1.04% VS 1.27%; necrosis: 0.67% VS 1.11%), granulocytes, or monocytes between those two groups.Conclusion: There is severe immunosuppression in critically ill COVID-19 patients. Redistribution of T cells might be the main reason for lymphocytic decline. Decreasing the infiltration of T lymphocytes in the lung may be beneficial for the treatment of COVID-19.Keywords: COVID-19, T lymphocytes, PD-1, HLA-DR, redistribution
format	article
author	Xu J Liu Z Liu H Luo Y Kang K Li X Yang W Fei D Wang C Yu K
author_facet	Xu J Liu Z Liu H Luo Y Kang K Li X Yang W Fei D Wang C Yu K
author_sort	Xu J
title	Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study
title_short	Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study
title_full	Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study
title_fullStr	Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study
title_full_unstemmed	Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study
title_sort	decreased t cell levels in critically ill coronavirus patients: single-center, prospective and observational study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ec1ea104f69c4c2cb24b00ea37f763cc
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Decreased T Cell Levels in Critically Ill Coronavirus Patients: Single-Center, Prospective and Observational Study

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