TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

Tuberous sclerosis complex (TSC) is a multiorgan disease that can lead to hyperactive mTORC1 due to deficient TSC1 or TSC2 protein function. Here, the authors find that despite high mTORC1 activity, TFEB localizes to the nucleus and drives lysosomal gene expression via a non-canonical Rag-dependent...

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Autores principales:	Nicola Alesi, Elie W. Akl, Damir Khabibullin, Heng-Jia Liu, Anna S. Nidhiry, Emma R. Garner, Harilaos Filippakis, Hilaire C. Lam, Wei Shi, Srinivas R. Viswanathan, Manrico Morroni, Shawn M. Ferguson, Elizabeth P. Henske
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec225f1e3e484d6c80c74d6195d73b5c
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spelling	oai:doaj.org-article:ec225f1e3e484d6c80c74d6195d73b5c2021-12-02T16:08:13ZTSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism10.1038/s41467-021-24499-62041-1723https://doaj.org/article/ec225f1e3e484d6c80c74d6195d73b5c2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24499-6https://doaj.org/toc/2041-1723Tuberous sclerosis complex (TSC) is a multiorgan disease that can lead to hyperactive mTORC1 due to deficient TSC1 or TSC2 protein function. Here, the authors find that despite high mTORC1 activity, TFEB localizes to the nucleus and drives lysosomal gene expression via a non-canonical Rag-dependent mechanism.Nicola AlesiElie W. AklDamir KhabibullinHeng-Jia LiuAnna S. NidhiryEmma R. GarnerHarilaos FilippakisHilaire C. LamWei ShiSrinivas R. ViswanathanManrico MorroniShawn M. FergusonElizabeth P. HenskeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicola Alesi Elie W. Akl Damir Khabibullin Heng-Jia Liu Anna S. Nidhiry Emma R. Garner Harilaos Filippakis Hilaire C. Lam Wei Shi Srinivas R. Viswanathan Manrico Morroni Shawn M. Ferguson Elizabeth P. Henske TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
description	Tuberous sclerosis complex (TSC) is a multiorgan disease that can lead to hyperactive mTORC1 due to deficient TSC1 or TSC2 protein function. Here, the authors find that despite high mTORC1 activity, TFEB localizes to the nucleus and drives lysosomal gene expression via a non-canonical Rag-dependent mechanism.
format	article
author	Nicola Alesi Elie W. Akl Damir Khabibullin Heng-Jia Liu Anna S. Nidhiry Emma R. Garner Harilaos Filippakis Hilaire C. Lam Wei Shi Srinivas R. Viswanathan Manrico Morroni Shawn M. Ferguson Elizabeth P. Henske
author_facet	Nicola Alesi Elie W. Akl Damir Khabibullin Heng-Jia Liu Anna S. Nidhiry Emma R. Garner Harilaos Filippakis Hilaire C. Lam Wei Shi Srinivas R. Viswanathan Manrico Morroni Shawn M. Ferguson Elizabeth P. Henske
author_sort	Nicola Alesi
title	TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
title_short	TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
title_full	TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
title_fullStr	TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
title_full_unstemmed	TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism
title_sort	tsc2 regulates lysosome biogenesis via a non-canonical ragc and tfeb-dependent mechanism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec225f1e3e484d6c80c74d6195d73b5c
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TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism

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