Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells

Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells

Precise genome editing in human pluripotent stem cells requires the development of methods for rapid and efficient genetic manipulation. Here, the authors screen for small molecules that enhance CRISPR-Cpf1-mediated genome engineering.

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Autores principales: Xiaojie Ma, Xi Chen, Yan Jin, Wenyan Ge, Weiyun Wang, Linghao Kong, Junfang Ji, Xing Guo, Jun Huang, Xin-Hua Feng, Junfen Fu, Saiyong Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/ec2270ca0b5d494c89b4bf30fa1bc379
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spelling oai:doaj.org-article:ec2270ca0b5d494c89b4bf30fa1bc3792021-12-02T15:33:34ZSmall molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells10.1038/s41467-018-03760-52041-1723https://doaj.org/article/ec2270ca0b5d494c89b4bf30fa1bc3792018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03760-5https://doaj.org/toc/2041-1723Precise genome editing in human pluripotent stem cells requires the development of methods for rapid and efficient genetic manipulation. Here, the authors screen for small molecules that enhance CRISPR-Cpf1-mediated genome engineering.Xiaojie MaXi ChenYan JinWenyan GeWeiyun WangLinghao KongJunfang JiXing GuoJun HuangXin-Hua FengJunfen FuSaiyong ZhuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaojie Ma
Xi Chen
Yan Jin
Wenyan Ge
Weiyun Wang
Linghao Kong
Junfang Ji
Xing Guo
Jun Huang
Xin-Hua Feng
Junfen Fu
Saiyong Zhu
Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells
description Precise genome editing in human pluripotent stem cells requires the development of methods for rapid and efficient genetic manipulation. Here, the authors screen for small molecules that enhance CRISPR-Cpf1-mediated genome engineering.
format article
author Xiaojie Ma
Xi Chen
Yan Jin
Wenyan Ge
Weiyun Wang
Linghao Kong
Junfang Ji
Xing Guo
Jun Huang
Xin-Hua Feng
Junfen Fu
Saiyong Zhu
author_facet Xiaojie Ma
Xi Chen
Yan Jin
Wenyan Ge
Weiyun Wang
Linghao Kong
Junfang Ji
Xing Guo
Jun Huang
Xin-Hua Feng
Junfen Fu
Saiyong Zhu
author_sort Xiaojie Ma
title Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells
title_short Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells
title_full Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells
title_fullStr Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells
title_full_unstemmed Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells
title_sort small molecules promote crispr-cpf1-mediated genome editing in human pluripotent stem cells
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ec2270ca0b5d494c89b4bf30fa1bc379
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AT linghaokong smallmoleculespromotecrisprcpf1mediatedgenomeeditinginhumanpluripotentstemcells
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AT junhuang smallmoleculespromotecrisprcpf1mediatedgenomeeditinginhumanpluripotentstemcells
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