Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

High homocysteine plasma levels are associated with cardiovascular diseases. Here, Li and colleagues find that homocysteine aggravates vascular injury by direct binding to the angiotensin II type 1 receptor (AT1R), identifying AT1R inhibition as a potential strategy to counteract the deleterious vas...

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Autores principales:	Tuoyi Li, Bing Yu, Zhixin Liu, Jingyuan Li, Mingliang Ma, Yingbao Wang, Mingjiang Zhu, Huiyong Yin, Xiaofeng Wang, Yi Fu, Fang Yu, Xian Wang, Xiaohong Fang, Jinpeng Sun, Wei Kong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec2a12665fee45ed9f9404d59ef5312a
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spelling	oai:doaj.org-article:ec2a12665fee45ed9f9404d59ef5312a2021-12-02T17:33:02ZHomocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury10.1038/s41467-017-02401-72041-1723https://doaj.org/article/ec2a12665fee45ed9f9404d59ef5312a2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02401-7https://doaj.org/toc/2041-1723High homocysteine plasma levels are associated with cardiovascular diseases. Here, Li and colleagues find that homocysteine aggravates vascular injury by direct binding to the angiotensin II type 1 receptor (AT1R), identifying AT1R inhibition as a potential strategy to counteract the deleterious vascular effects of hyperhomocysteinemia.Tuoyi LiBing YuZhixin LiuJingyuan LiMingliang MaYingbao WangMingjiang ZhuHuiyong YinXiaofeng WangYi FuFang YuXian WangXiaohong FangJinpeng SunWei KongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tuoyi Li Bing Yu Zhixin Liu Jingyuan Li Mingliang Ma Yingbao Wang Mingjiang Zhu Huiyong Yin Xiaofeng Wang Yi Fu Fang Yu Xian Wang Xiaohong Fang Jinpeng Sun Wei Kong Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
description	High homocysteine plasma levels are associated with cardiovascular diseases. Here, Li and colleagues find that homocysteine aggravates vascular injury by direct binding to the angiotensin II type 1 receptor (AT1R), identifying AT1R inhibition as a potential strategy to counteract the deleterious vascular effects of hyperhomocysteinemia.
format	article
author	Tuoyi Li Bing Yu Zhixin Liu Jingyuan Li Mingliang Ma Yingbao Wang Mingjiang Zhu Huiyong Yin Xiaofeng Wang Yi Fu Fang Yu Xian Wang Xiaohong Fang Jinpeng Sun Wei Kong
author_facet	Tuoyi Li Bing Yu Zhixin Liu Jingyuan Li Mingliang Ma Yingbao Wang Mingjiang Zhu Huiyong Yin Xiaofeng Wang Yi Fu Fang Yu Xian Wang Xiaohong Fang Jinpeng Sun Wei Kong
author_sort	Tuoyi Li
title	Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
title_short	Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
title_full	Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
title_fullStr	Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
title_full_unstemmed	Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
title_sort	homocysteine directly interacts and activates the angiotensin ii type i receptor to aggravate vascular injury
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ec2a12665fee45ed9f9404d59ef5312a
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Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury

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