Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Early life trauma has been associated with multiple sclerosis, but the causal link is unclear. Here the authors show in mice that early life trauma can result in IFN-β-resistant EAE as a result of β-adrenergic desensitization in immune cells and that a β1 adrenergic receptor agonist can reverse this...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yee Ming Khaw, Danish Majid, Sungjong Oh, Eunjoo Kang, Makoto Inoue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ec2bf3b33bf84e75958276478c795d7f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ec2bf3b33bf84e75958276478c795d7f
record_format	dspace
spelling	oai:doaj.org-article:ec2bf3b33bf84e75958276478c795d7f2021-12-02T15:16:22ZEarly-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling10.1038/s41467-020-20302-02041-1723https://doaj.org/article/ec2bf3b33bf84e75958276478c795d7f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20302-0https://doaj.org/toc/2041-1723Early life trauma has been associated with multiple sclerosis, but the causal link is unclear. Here the authors show in mice that early life trauma can result in IFN-β-resistant EAE as a result of β-adrenergic desensitization in immune cells and that a β1 adrenergic receptor agonist can reverse this susceptibility.Yee Ming KhawDanish MajidSungjong OhEunjoo KangMakoto InoueNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yee Ming Khaw Danish Majid Sungjong Oh Eunjoo Kang Makoto Inoue Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
description	Early life trauma has been associated with multiple sclerosis, but the causal link is unclear. Here the authors show in mice that early life trauma can result in IFN-β-resistant EAE as a result of β-adrenergic desensitization in immune cells and that a β1 adrenergic receptor agonist can reverse this susceptibility.
format	article
author	Yee Ming Khaw Danish Majid Sungjong Oh Eunjoo Kang Makoto Inoue
author_facet	Yee Ming Khaw Danish Majid Sungjong Oh Eunjoo Kang Makoto Inoue
author_sort	Yee Ming Khaw
title	Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_short	Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_full	Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_fullStr	Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_full_unstemmed	Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
title_sort	early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ec2bf3b33bf84e75958276478c795d7f
work_keys_str_mv	AT yeemingkhaw earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling AT danishmajid earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling AT sungjongoh earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling AT eunjookang earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling AT makotoinoue earlylifetraumatriggersinterferonbresistanceandneurodegenerationinamultiplesclerosismodelviadownregulatedb1adrenergicsignaling
_version_	1718387544430739456

Early-life-trauma triggers interferon-β resistance and neurodegeneration in a multiple sclerosis model via downregulated β1-adrenergic signaling

Ejemplares similares