Effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method

Mahshid Kalani, Robiah YunusChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaAbstract: The reported work demonstrates and discusses the effect of supercritical fluid density (pressure and temperature of supercritical fluid carbo...

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Autores principales:	Kalani M, Yunus R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ec2d0ff6730b4e448bda2e57e6998b3d
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spelling	oai:doaj.org-article:ec2d0ff6730b4e448bda2e57e6998b3d2021-12-02T02:10:29ZEffect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method1176-91141178-2013https://doaj.org/article/ec2d0ff6730b4e448bda2e57e6998b3d2012-04-01T00:00:00Zhttp://www.dovepress.com/effect-of-supercritical-fluid-density-on-nanoencapsulated-drug-particl-a9784https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Mahshid Kalani, Robiah YunusChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaAbstract: The reported work demonstrates and discusses the effect of supercritical fluid density (pressure and temperature of supercritical fluid carbon dioxide) on particle size and distribution using the supercritical antisolvent (SAS) method in the purpose of drug encapsulation. In this study, paracetamol was encapsulated inside L-polylactic acid, a semicrystalline polymer, with different process parameters, including pressure and temperature, using the SAS process. The morphology and particle size of the prepared nanoparticles were determined by scanning electron microscopy and transmission electron microscopy. The results revealed that increasing temperature enhanced mean particle size due to the plasticizing effect. Furthermore, increasing pressure enhanced molecular interaction and solubility; thus, particle size was reduced. Transmission electron microscopy images defined the internal structure of nanoparticles. Thermal characteristics of nanoparticles were also investigated via differential scanning calorimetry. Furthermore, X-ray diffraction pattern revealed the changes in crystallinity structure during the SAS process. In vitro drug release analysis determined the sustained release of paracetamol in over 4 weeks.Keywords: supercritical antisolvent, encapsulation, supercritical fluid density, particle sizeKalani MYunus RDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2165-2172 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kalani M Yunus R Effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method
description	Mahshid Kalani, Robiah YunusChemical and Environmental Engineering, Faculty of Engineering, University Putra Malaysia, Selangor Darul Ehsan, MalaysiaAbstract: The reported work demonstrates and discusses the effect of supercritical fluid density (pressure and temperature of supercritical fluid carbon dioxide) on particle size and distribution using the supercritical antisolvent (SAS) method in the purpose of drug encapsulation. In this study, paracetamol was encapsulated inside L-polylactic acid, a semicrystalline polymer, with different process parameters, including pressure and temperature, using the SAS process. The morphology and particle size of the prepared nanoparticles were determined by scanning electron microscopy and transmission electron microscopy. The results revealed that increasing temperature enhanced mean particle size due to the plasticizing effect. Furthermore, increasing pressure enhanced molecular interaction and solubility; thus, particle size was reduced. Transmission electron microscopy images defined the internal structure of nanoparticles. Thermal characteristics of nanoparticles were also investigated via differential scanning calorimetry. Furthermore, X-ray diffraction pattern revealed the changes in crystallinity structure during the SAS process. In vitro drug release analysis determined the sustained release of paracetamol in over 4 weeks.Keywords: supercritical antisolvent, encapsulation, supercritical fluid density, particle size
format	article
author	Kalani M Yunus R
author_facet	Kalani M Yunus R
author_sort	Kalani M
title	Effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method
title_short	Effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method
title_full	Effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method
title_fullStr	Effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method
title_full_unstemmed	Effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method
title_sort	effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/ec2d0ff6730b4e448bda2e57e6998b3d
work_keys_str_mv	AT kalanim effectofsupercriticalfluiddensityonnanoencapsulateddrugparticlesizeusingthesupercriticalantisolventmethod AT yunusr effectofsupercriticalfluiddensityonnanoencapsulateddrugparticlesizeusingthesupercriticalantisolventmethod
_version_	1718402685167730688

Effect of supercritical fluid density on nanoencapsulated drug particle size using the supercritical antisolvent method

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