Determinants of activity of brown adipose tissue in lymphoma patients

Abstract The determinants of brown adipose tissue (BAT) activity are not yet known in detail but might serve as future therapeutic targets against obesity and the metabolic syndrome. We analyzed 235 datasets of lymphoma patients with two PET/CT examinations at different time points retrospectively....

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Autores principales:	Cornelia Brendle, Norbert Stefan, Eva Grams, Martin Soekler, Christian la Fougère, Christina Pfannenberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ec2d65b4a6144c76aed29a804af80d32
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spelling	oai:doaj.org-article:ec2d65b4a6144c76aed29a804af80d322021-12-02T11:43:36ZDeterminants of activity of brown adipose tissue in lymphoma patients10.1038/s41598-020-78419-72045-2322https://doaj.org/article/ec2d65b4a6144c76aed29a804af80d322020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78419-7https://doaj.org/toc/2045-2322Abstract The determinants of brown adipose tissue (BAT) activity are not yet known in detail but might serve as future therapeutic targets against obesity and the metabolic syndrome. We analyzed 235 datasets of lymphoma patients with two PET/CT examinations at different time points retrospectively. We assessed the anthropometric characteristics, features related to the metabolic syndrome, thyroid dysfunction, season of the PET/CT examination, weight change, prior cancer history, lymphoma subgroups, disease activity, and specific lymphoma-related therapies, and evaluated their association with BAT activity. We found BAT activity in 12% of all examinations, and the incidence of BAT activity after initially negative examinations was 10%. In multivariate regression analysis, the prevalence of BAT activity was associated with age, body mass index, sex, the season of the examination, diabetes mellitus, arterial hypertension, and medication on the beta-receptors. New BAT activity arose more often in patients without preceding lymphoma-related therapy. No specific medication was associated with BAT activity. In conclusion, this study confirms the potential connection of BAT with the metabolic syndrome. Preceding lymphoma-related therapy might have an inhibitory effect on the recruitment of BAT.Cornelia BrendleNorbert StefanEva GramsMartin SoeklerChristian la FougèreChristina PfannenbergNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cornelia Brendle Norbert Stefan Eva Grams Martin Soekler Christian la Fougère Christina Pfannenberg Determinants of activity of brown adipose tissue in lymphoma patients
description	Abstract The determinants of brown adipose tissue (BAT) activity are not yet known in detail but might serve as future therapeutic targets against obesity and the metabolic syndrome. We analyzed 235 datasets of lymphoma patients with two PET/CT examinations at different time points retrospectively. We assessed the anthropometric characteristics, features related to the metabolic syndrome, thyroid dysfunction, season of the PET/CT examination, weight change, prior cancer history, lymphoma subgroups, disease activity, and specific lymphoma-related therapies, and evaluated their association with BAT activity. We found BAT activity in 12% of all examinations, and the incidence of BAT activity after initially negative examinations was 10%. In multivariate regression analysis, the prevalence of BAT activity was associated with age, body mass index, sex, the season of the examination, diabetes mellitus, arterial hypertension, and medication on the beta-receptors. New BAT activity arose more often in patients without preceding lymphoma-related therapy. No specific medication was associated with BAT activity. In conclusion, this study confirms the potential connection of BAT with the metabolic syndrome. Preceding lymphoma-related therapy might have an inhibitory effect on the recruitment of BAT.
format	article
author	Cornelia Brendle Norbert Stefan Eva Grams Martin Soekler Christian la Fougère Christina Pfannenberg
author_facet	Cornelia Brendle Norbert Stefan Eva Grams Martin Soekler Christian la Fougère Christina Pfannenberg
author_sort	Cornelia Brendle
title	Determinants of activity of brown adipose tissue in lymphoma patients
title_short	Determinants of activity of brown adipose tissue in lymphoma patients
title_full	Determinants of activity of brown adipose tissue in lymphoma patients
title_fullStr	Determinants of activity of brown adipose tissue in lymphoma patients
title_full_unstemmed	Determinants of activity of brown adipose tissue in lymphoma patients
title_sort	determinants of activity of brown adipose tissue in lymphoma patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ec2d65b4a6144c76aed29a804af80d32
work_keys_str_mv	AT corneliabrendle determinantsofactivityofbrownadiposetissueinlymphomapatients AT norbertstefan determinantsofactivityofbrownadiposetissueinlymphomapatients AT evagrams determinantsofactivityofbrownadiposetissueinlymphomapatients AT martinsoekler determinantsofactivityofbrownadiposetissueinlymphomapatients AT christianlafougere determinantsofactivityofbrownadiposetissueinlymphomapatients AT christinapfannenberg determinantsofactivityofbrownadiposetissueinlymphomapatients
_version_	1718395376129540096

Determinants of activity of brown adipose tissue in lymphoma patients

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